The effect of black cumin ( L.) on the number of glial cells in white rats () exposed to cigarette smoke.

BACKGROUND

Cigarette smoke is known to have harmful effects on the brain, particularly on glial cells, which play a crucial role in maintaining the health and functionality of the central nervous system. (black cumin) has been reported to have neuroprotective properties, but its effects on glial cells in the cerebellum and cerebrum when exposed to cigarette smoke are not well understood.

AIM

This study aimed to determine the benefits of on the number of glial cells in the cerebellum and cerebrum of white rats () exposed to cigarette smoke.

METHODS

Thirty white rats weighing approximately 105 g were divided into five groups: K (control group, no exposure to cigarette smoke and without given ), K+ (exposed to cigarette smoke, 2 cigarettes/day, and 0.5% CMC), and three treatment groups (P1, P2, and P3) exposed to cigarette smoke, 2 cigarettes/day, with dosages of 300, 600, and 1200 mg/kg BW, respectively. The number of glial cells in the cerebellum and cerebrum was examined under a microscope at 400x magnification. Data were analyzed using a one-way ANOVA test, followed by the Duncan test.

RESULTS

Significant difference ( < 0.05) in the number of glial cells in both the cerebellum and cerebrum between the control and treatment groups.

CONCLUSION

The administration of , particularly at a dosage of 1,200 mg/kg BW/day, significantly increased and maintained the number of glial cells in the cerebellum and cerebrum of rats exposed to cigarette smoke.