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减轻镉毒性：咖啡因在减轻氧化应激中的作用。

Mitigating Cadmium Toxicity: Role of Caffeine in the Reduction of Oxidative Stress.

作者信息

Aljazzar Ahmed

机构信息

Department of Pathology, College of Veterinary Medicine, King Faisal University, Al Hofuf, Saudi Arabia.

出版信息

Open Vet J. 2025 Feb;15(2):931-938. doi: 10.5455/OVJ.2025.v15.i2.42. Epub 2025 Feb 28.

DOI:10.5455/OVJ.2025.v15.i2.42
PMID:40201837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11974268/
Abstract

BACKGROUND

Cadmium (Cd) is a common environmental pollutant that causes severe health issues. Many studies have proposed antioxidant foods to combat Cd toxicity. One such antioxidant agent is caffeine, and hence, this study investigated its effects.

AIM

To investigate the effect of caffeine as an antioxidant agent against Cd toxicity.

METHODS

Twelve male albino mice were divided into three groups of four: Group 1: Administered 1 ml of saline orally for 7 days and injected with 1 ml of saline subcutaneously (S/C) on the eighth day. Group 2: Patients were orally administered 1 ml of saline for 7 days and injected with 1-ml of cadmium chloride (CdCl2) S/C on the eighth day. Group 3: Administered 1 ml of caffeine orally for seven days and injected with CdCl2 S/C on the eighth day.

RESULTS

Results showed that caffeine can reduce Cd-induced testicular hemorrhage, lung injury, and kidney injury. Additionally, caffeine was found to significantly reduce the Cd-induced inflammatory response in lung-associated lymphoid tissue.

CONCLUSION

These findings suggest that the daily intake of caffeine could protect against Cd toxicity.

摘要

背景

镉（Cd）是一种常见的环境污染物，会引发严重的健康问题。许多研究提出食用抗氧化食物来对抗镉毒性。咖啡因就是这样一种抗氧化剂，因此，本研究对其效果进行了调查。

目的

研究咖啡因作为抗氧化剂对抗镉毒性的效果。

方法

将12只雄性白化小鼠分为三组，每组4只：第1组：连续7天口服1毫升生理盐水，并在第8天皮下注射（S/C）1毫升生理盐水。第2组：连续7天口服1毫升生理盐水，并在第8天皮下注射1毫升氯化镉（CdCl2）。第3组：连续7天口服1毫升咖啡因，并在第8天皮下注射CdCl2。

结果

结果显示，咖啡因可以减轻镉诱导的睾丸出血、肺损伤和肾损伤。此外，发现咖啡因能显著减轻镉诱导的肺相关淋巴组织炎症反应。

结论

这些研究结果表明，每日摄入咖啡因可以预防镉毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/6ba3e84d8578/OpenVetJ-15-931-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/876806bdebea/OpenVetJ-15-931-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/21149abb73ee/OpenVetJ-15-931-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/55e2ceaa1750/OpenVetJ-15-931-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/f76219b2d08c/OpenVetJ-15-931-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/6ba3e84d8578/OpenVetJ-15-931-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/876806bdebea/OpenVetJ-15-931-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/21149abb73ee/OpenVetJ-15-931-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/55e2ceaa1750/OpenVetJ-15-931-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/f76219b2d08c/OpenVetJ-15-931-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a52/11974268/6ba3e84d8578/OpenVetJ-15-931-g005.jpg

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本文引用的文献

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Long-term cadmium exposure induces chronic obstructive pulmonary disease-like lung lesions in a mouse model.长期镉暴露在小鼠模型中诱发慢性阻塞性肺疾病样肺部病变。
Sci Total Environ. 2023 Jun 25;879:163073. doi: 10.1016/j.scitotenv.2023.163073. Epub 2023 Mar 23.
3
Interactions between cadmium, lead, mercury, and arsenic and depression: A molecular mechanism involved.
镉、铅、汞和砷与抑郁症的相互作用：涉及的分子机制。
J Affect Disord. 2023 Apr 14;327:315-329. doi: 10.1016/j.jad.2023.02.013. Epub 2023 Feb 7.
4
Caffeine and Its Antioxidant Properties-It Is All about Dose and Source.咖啡因及其抗氧化特性——关键在于剂量和来源。
Int J Mol Sci. 2022 Oct 28;23(21):13074. doi: 10.3390/ijms232113074.
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Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms.佛手柑汁富含类黄酮的提取物单独或与姜黄素和白藜芦醇联合使用，通过增强不同的防御机制，可对抗镉诱导的小鼠肾损伤。
Biomedicines. 2021 Nov 30;9(12):1797. doi: 10.3390/biomedicines9121797.
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Effects of Cadmium Exposure on the Immune System and Immunoregulation.镉暴露对免疫系统和免疫调节的影响。
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