Kim Hyo-Sung, Kim Han-Jun, Hwang Hyun-Jeong, Oh Sukhun, Do Sun Hee
Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, CA, United States.
Vet Med (Praha). 2021 May 3;66(5):225-232. doi: 10.17221/115/2020-VETMED. eCollection 2021 May.
A 3-year-old castrated male ferret was suspected to have lymphoma based on a markedly enlarged mesenteric lymph node. Hodgkin's-like lymphoma (HLL) was suspected because numerous Reed-Sternberg-like cells were observed in the fine-needle aspiration biopsy of the mesenteric lymph node. In the post-mortem histopathology, neoplastic cells were invasively proliferated not only in the mesenteric lymph nodes, but also in the liver and spleen. Immunohistochemically, most neoplastic cells were positive for vimentin and BLA-36, weakly positive for CD20, and negative for Pax5, CD79a, CD3, CD45, and Iba-1, demonstrating similarity to human Hodgkin's lymphoma (HL). In addition, a prominent programmed cell death protein1 (PD-1) expression was observed at the sites showing malignant tumour proliferation. HLL in non-human beings can be morphologically and immunophenotypically similar to human HL, but the prognosis and clinical outcome may differ. This is the first study analysing the PD-1 expression in a ferret, suggesting that PD-1 can be a novel diagnostic and prognostic factor in a similar manner to humans.
一只3岁去势雄性雪貂因肠系膜淋巴结明显肿大而被怀疑患有淋巴瘤。由于在肠系膜淋巴结细针穿刺活检中观察到大量里德-施特恩伯格样细胞，怀疑为霍奇金样淋巴瘤（HLL）。尸检组织病理学检查发现，肿瘤细胞不仅在肠系膜淋巴结中浸润性增殖，还在肝脏和脾脏中浸润性增殖。免疫组化显示，大多数肿瘤细胞波形蛋白和BLA - 36呈阳性，CD20弱阳性，Pax5、CD79a、CD3、CD45和Iba - 1呈阴性，与人霍奇金淋巴瘤（HL）相似。此外，在显示恶性肿瘤增殖的部位观察到明显的程序性细胞死亡蛋白1（PD - 1）表达。非人类的HLL在形态学和免疫表型上可能与人HL相似，但预后和临床结果可能不同。这是第一项分析雪貂中PD - 1表达的研究，表明PD - 1可以像在人类中一样成为一种新的诊断和预后因素。
