Aseri Parang, Chitara Gayatri, Choudhary Mahendra
General Surgery, Dr. Sampurnanand (SN) Medical College, Jodhpur, IND.
Anaesthesiology, Dr. Sampurnanand (SN) Medical College, Jodhpur, IND.
Cureus. 2025 Mar 9;17(3):e80285. doi: 10.7759/cureus.80285. eCollection 2025 Mar.
Background Carcinoembryonic antigen (CEA) has been widely used as a prognostic marker in colorectal cancer for decades. Elevated levels of prolactin have also been observed in various cancers, including CRC; however, the role of elevated prolactin in colorectal cancer remains unclear. Objective This study aimed to investigate the correlation between plasma prolactin and CEA levels in patients with colorectal cancer. Materials and methods In this observational study, 80 colorectal cancer patients were included. Serum levels of prolactin and CEA were measured using chemiluminescence assay (Siemens AdviaCentaur XP, Siemens Healthineers, Erlangen, Germany). Statistical analysis was performed using the chi-square test, unpaired t-test, and analysis of variance (ANOVA) to evaluate correlations between the two biomarkers. Results Our results showed elevated levels of both plasma prolactin and CEA in colorectal cancer patients. A positive correlation was found between serum prolactin and CEA levels in the patient population. Conclusion The present study found elevated serum prolactin levels in most patients with raised CEA levels. Further research is required to better understand the role of prolactin as a potential prognostic factor in colorectal cancer and to establish the relationship between serum prolactin and CEA.
背景 几十年来，癌胚抗原（CEA）一直被广泛用作结直肠癌的预后标志物。在包括结直肠癌在内的各种癌症中也观察到催乳素水平升高；然而，催乳素升高在结直肠癌中的作用仍不清楚。目的 本研究旨在探讨结直肠癌患者血浆催乳素与CEA水平之间的相关性。材料和方法 在这项观察性研究中，纳入了80例结直肠癌患者。采用化学发光分析法（德国西门子公司的AdviaCentaur XP，西门子医疗，埃尔朗根）测量催乳素和CEA的血清水平。使用卡方检验、非配对t检验和方差分析（ANOVA）进行统计分析，以评估这两种生物标志物之间的相关性。结果 我们的结果显示，结直肠癌患者的血浆催乳素和CEA水平均升高。在患者群体中，血清催乳素与CEA水平之间存在正相关。结论 本研究发现，大多数CEA水平升高的患者血清催乳素水平也升高。需要进一步研究以更好地了解催乳素作为结直肠癌潜在预后因素的作用，并确定血清催乳素与CEA之间的关系。
