Xie Dalu, Yan Xueke, Shang Wenzhao, Ren Hao, Wen Wei, Tang Ben Zhong, Su Huifang
Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, Guangdong 518172, P.R. China.
ACS Nano. 2025 Apr 22;19(15):14972-14986. doi: 10.1021/acsnano.5c00942. Epub 2025 Apr 9.
Inspired by the clinical application of thermotherapy to promote the efficacy of radiotherapy, this study demonstrates the multimodal diagnostic application of pure organic nanoparticles in the combined treatment of tumors through imaging and photothermal properties. The nanoparticles developed in this study demonstrated unique properties and multiple functionalities, including excellent photostability and thermostability, strong fluorescence emission in the near-infrared-II (NIR-II) region, extremely high photothermal conversion efficiency, good biocompatibility, significant radiosensitizing properties, and effective tumor site accumulation. and evaluations demonstrated that these nanoparticles are ideal candidates for synergistic photothermal radiotherapy guided by NIR-II fluorescence, NIR-I photoacoustic, and photothermal trimodal imaging. They act as radiosensitizers by alleviating the hypoxic tumor microenvironment, modulating the cell cycle, and inducing apoptosis and immunogenic cell death during radiotherapy, which may provide a potential approach for the clinical treatment of tumors.
受热疗法临床应用以提高放射治疗疗效的启发，本研究展示了纯有机纳米颗粒通过成像和光热特性在肿瘤联合治疗中的多模态诊断应用。本研究中开发的纳米颗粒表现出独特的性质和多种功能，包括优异的光稳定性和热稳定性、近红外二区（NIR-II）区域的强荧光发射、极高的光热转换效率、良好的生物相容性、显著的放射增敏特性以及有效的肿瘤部位聚集。评估表明，这些纳米颗粒是由NIR-II荧光、NIR-I光声和光热三模态成像引导的协同光热放疗的理想候选者。它们通过缓解肿瘤缺氧微环境、调节细胞周期以及在放疗期间诱导细胞凋亡和免疫原性细胞死亡来充当放射增敏剂，这可能为肿瘤的临床治疗提供一种潜在方法。
