基于多功能近红外二区聚集诱导发光材料的多模态成像引导光热免疫治疗
Multimodal Imaging-Guided Photothermal Immunotherapy Based on a Versatile NIR-II Aggregation-Induced Emission Luminogen.
机构信息
Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
出版信息
Angew Chem Int Ed Engl. 2022 Jul 4;61(27):e202202614. doi: 10.1002/anie.202202614. Epub 2022 May 5.
Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation-induced emission, namely TPA-BT-DPTQ, was designed and prepared based on benzo[c]thiophene unit as a building block; it can be used for simultaneous fluorescence imaging (FLI) in the second near-infrared (NIR-II) window, photoacoustic imaging (PAI), photothermal imaging (PTI), and thermal eradication of tumors. Further experiments validate that photothermal therapy (PTT) mediated by TPA-BT-DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of tumors at distant sites. Furthermore, PTT combining a programmed death-ligand 1 (PD-L1) antibody prevents the metastasis and recurrence of cancer by potentiating the effect of immunotherapy.
协同光热免疫疗法因其对原肿瘤和远隔肿瘤的治疗效果相互增强而受到极大关注。在此，基于苯并[c]噻吩单元作为构建块，设计并制备了一种具有聚集诱导发射的多功能治疗剂 TPA-BT-DPTQ；它可用于在近红外二区（NIR-II）同时荧光成像（FLI）、光声成像（PAI）、光热成像（PTI）和热消融肿瘤。进一步的实验验证了 TPA-BT-DPTQ 纳米粒子介导的光热疗法（PTT）不仅破坏了原发性肿瘤，而且增强了免疫原性，从而进一步抑制了远处部位肿瘤的生长。此外，通过增强免疫疗法的效果，将 PTT 与程序性死亡配体 1（PD-L1）抗体联合使用可防止癌症转移和复发。
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