Lamoš Martin, Bočková Martina, Missey Florian, Lubrano Claudia, de Araújo E Silva Mariane, Trajlínek Jan, Studnička Ondřej, Daniel Pavel, Carron Romain, Jirsa Viktor, Chrastina Jan, Jančálek Radim, Glowacki Eric Daniel, Cassara Antonino, Neufeld Esra, Rektorová Irena, Williamson Adam
Brain and Mind Research Program, Central European Institute of Technology, Masaryk University, Brno, Czechia.
First Department of Neurology, Masaryk University School of Medicine, St. Anne's Hospital, Brno, Czechia.
Mov Disord. 2025 Jun;40(6):1051-1060. doi: 10.1002/mds.30134. Epub 2025 Apr 9.
Temporal interference stimulation (TIS) is a novel noninvasive electrical stimulation technique to focally modulate deep brain regions; a minimum of two high-frequency signals (f and f > 1 kHz) interfere to create an envelope-modulated signal at a deep brain target with the frequency of modulation equal to the difference frequency: Δf = |f - f|.
The goals of this study were to verify the capability of TIS to modulate the subthalamic nucleus (STN) with Δf and to compare the effect of TIS and conventional deep brain stimulation (DBS) on the STN beta oscillations in patients with Parkinson's disease (PD).
DBS leads remained externalized after implantation, allowing local field potentials (LFPs) recordings in eight patients with PD. TIS was performed initially by two pairs (f = 9.00 kHz; f = 9.13 kHz, 4 mA peak-peak per pair maximum) of scalp electrodes placed in temporoparietal regions to focus the envelope signal maximum (Δf = 130 Hz) at the motor part of the STN target.
The comparison between the baseline LFPs and recordings after TIS and conventional DBS sessions showed substantial suppression of high beta power peak after both types of stimulation in all patients.
TIS has the potential to effectively modulate the STN and reduce the beta oscillatory activity in a completely noninvasive manner, as is traditionally possible only with intracranial DBS. Future studies should confirm the clinical effectiveness of TIS and determine whether TIS could be used to identify optimal DBS candidates and individualize DBS targets. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
时间干扰刺激（TIS）是一种新型的非侵入性电刺激技术，用于局部调节深部脑区；至少两个高频信号（f和f > 1kHz）相互干扰，在深部脑靶点处产生一个包络调制信号，其调制频率等于差频：Δf = |f - f|。
本研究的目的是验证TIS以Δf调节丘脑底核（STN）的能力，并比较TIS和传统深部脑刺激（DBS）对帕金森病（PD）患者STNβ振荡的影响。
植入后DBS电极仍保持体外化，以便对8例PD患者进行局部场电位（LFP）记录。最初通过放置在颞顶区域的两对头皮电极（f = 9.00kHz；f = 9.13kHz，每对最大峰峰值为4mA）进行TIS，以使包络信号最大值（Δf = 130Hz）聚焦于STN靶点的运动部分。
对所有患者在TIS和传统DBS治疗前后的LFP基线记录进行比较，结果显示两种刺激后高β功率峰值均有显著抑制。
TIS有可能以完全非侵入性的方式有效调节STN并降低β振荡活动，而传统上只有颅内DBS才能做到这一点。未来的研究应证实TIS的临床有效性，并确定TIS是否可用于识别最佳DBS候选者并使DBS靶点个体化。© 2025作者。《运动障碍》由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版。
