Yang Chenhao, Xu Yongxin, Feng Xiaofan, Wang Bowen, Du Yichao, Wang Kexin, Lü Jiaojiao, Huang Lingyan, Qian Zhenyu, Wang Zhen, Chen Nan, Zhou Junhong, Zhang Chencheng, Liu Yu
Key Laboratory of Exercise and Health Sciences of Ministry of Education, School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
School of Martial Arts, Shanghai University of Sport, Shanghai, China.
Mov Disord. 2024 Aug 12. doi: 10.1002/mds.29967.
Invasive deep brain stimulation (DBS) has been shown to be effective in treating patients with Parkinson's disease (PD), yet its clinical use is limited to patients at the advanced stage of the disease. Transcranial temporal interference stimulation (tTIS) may be a novel nonneurosurgical and safer alternative, yet its therapeutic potential remains unexplored.
This pilot study aims to examine the feasibility and safety of tTIS targeting the right globus pallidus internus (GPi) for motor symptoms in patients with PD.
Twelve participants with mild PD completed this randomized, double-blind, and sham-controlled experiment. Each of them received either 20-minute or sham tTIS of the right GPi. Before and immediately after the stimulation, participants completed the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) in the "medication-on" state to assess the motor symptoms. The blinding efficacy and side effects were also assessed.
tTIS was well tolerated by participants, with only mild, transient adverse effects reported. tTIS significantly reduced MDS-UPDRS-III scores by 6.64 points (14.7%), particularly in bradykinesia (23.5%) and tremor (15.3%). The left side showed more significant alleviation in motor symptoms, particularly bradykinesia, compared to the right side. Participants with severer bradykinesia and tremor before stimulation experienced greater improvement after tTIS.
This pilot study suggests that the tTIS, as a novel noninvasive DBS approach, is feasible and safe for alleviating motor symptoms in mild PD, especially bradykinesia and tremor. Future larger-scale and more definitive studies are needed to confirm the benefits. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
有创性脑深部电刺激（DBS）已被证明对治疗帕金森病（PD）患者有效，但其临床应用仅限于疾病晚期患者。经颅颞叶干扰刺激（tTIS）可能是一种新型的非神经外科且更安全的替代方法，但其治疗潜力仍未得到探索。
本试点研究旨在探讨针对右侧苍白球内侧部（GPi）进行tTIS治疗PD患者运动症状的可行性和安全性。
12名轻度PD患者完成了这项随机、双盲、假刺激对照实验。他们每人接受了20分钟的右侧GPi的tTIS或假刺激。在刺激前和刺激后即刻，参与者在“服药后”状态下完成运动障碍协会统一帕金森病评定量表（MDS-UPDRS-III）以评估运动症状。还评估了盲法效果和副作用。
参与者对tTIS耐受性良好，仅报告了轻微、短暂的不良反应。tTIS使MDS-UPDRS-III评分显著降低了6.64分（14.7%），尤其是在运动迟缓（23.5%）和震颤（15.3%）方面。与右侧相比，左侧运动症状的缓解更为显著，尤其是运动迟缓。刺激前运动迟缓及震颤较严重的参与者在tTIS后改善更大。
这项试点研究表明，tTIS作为一种新型非侵入性DBS方法，对于缓解轻度PD患者的运动症状是可行且安全的，尤其是运动迟缓和震颤。未来需要更大规模、更具确定性的研究来证实其益处。© 2024作者。《运动障碍》由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版。
