Prime Constance, Hooper William, Sassi Yosra Ghrib Ben, Doss Nejib, Chen Oliver
Sofibel-Church & Dwight, Levallois-Perret, France.
Church & Dwight, Princeton, New Jersey, USA.
J Cosmet Dermatol. 2025 Apr;24(4):e70107. doi: 10.1111/jocd.70107.
Rhinorrhea is a widespread condition related to common upper respiratory insults such as influenza and rhinitis, often accompanied by frequent nose cleansing resulting in skin irritation. This study evaluated the cutaneous acceptability and nourishing, soothing, protecting, and moisturizing effects of Sterimar Soothing Nose Cream on the skin around the nose in healthy adults.
We conducted an exploratory single-arm clinical trial in 33 adults (mean age 46 years) who blow their nose often (> 5 times/day) due to a cold or allergies and have sensitive, irritated/dry nose. Participants applied the cream topically on their noses twice daily for 14 days. Cutaneous acceptability and efficacy measures were assessed by participants and by the study dermatologist before, during, and after 14 days. Skin imaging analysis via the Visia camera system and skin hydration via Corneometer were also assessed. Participants also completed a questionnaire about overall product performance.
The dermatologist noted reduced (p < 0.001) redness, swelling, dryness, roughness, and itchiness, with improved (p < 0.001) hydration, softness, and flexibility after 7 and 14 days. Participants reported less (p < 0.05) dryness, redness, and discomfort, with 97% rating the cream's soothing effect as moderate to strong. The cream also increased (p < 0.0001) skin hydration by 14%, measured by Corneometer 30 min postapplication. No worsening of symptoms or adverse effects was reported. All participants found the cream pleasant, with most intending to purchase and continue use.
The results indicate that Sterimar soothing nose cream is effective in nourishing, soothing, protecting, and moisturizing the nasolabial zone, and is well tolerated.
鼻漏是一种与流感和鼻炎等常见上呼吸道感染相关的普遍病症，常伴有频繁清洁鼻腔，导致皮肤刺激。本研究评估了施巴舒缓鼻霜对健康成年人鼻周皮肤的皮肤可接受性以及滋养、舒缓、保护和保湿效果。
我们对33名成年人（平均年龄46岁）进行了一项探索性单臂临床试验，这些成年人因感冒或过敏经常擤鼻（每天>5次），且鼻子敏感、受刺激/干燥。参与者每天在鼻子上局部涂抹该乳膏两次，持续14天。在14天之前、期间和之后，由参与者和研究皮肤科医生评估皮肤可接受性和疗效指标。还通过Visia相机系统进行皮肤成像分析，并通过角质层水合测定仪评估皮肤水合作用。参与者还完成了一份关于产品总体性能的问卷。
皮肤科医生指出，在7天和14天后，发红、肿胀、干燥、粗糙和瘙痒减轻（p<0.001），水合作用、柔软度和柔韧性改善（p<0.001）。参与者报告干燥、发红和不适减轻（p<0.05），97%的人将该乳膏的舒缓效果评为中度至强烈。根据角质层水合测定仪在涂抹后30分钟测量，该乳膏还使皮肤水合作用增加了14%（p<0.0001）。未报告症状恶化或不良反应。所有参与者都觉得该乳膏宜人，大多数人打算购买并继续使用。
结果表明，施巴舒缓鼻霜在滋养、舒缓、保护和保湿鼻唇区域方面有效，且耐受性良好。
