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与高原运动相关的神经学表现

Neurological Manifestations Associated with Exercise at Altitude.

作者信息

Marengo A, Tejada M, Zirena I Hancco, Molina S

机构信息

Servicio de Neurología. Hospital Perrupato, San Martin, Mendoza, Argentina.

Càtedra de Neurología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, 5500, Argentina.

出版信息

Curr Neurol Neurosci Rep. 2025 Apr 9;25(1):29. doi: 10.1007/s11910-025-01418-6.

Abstract

PURPOSE OF REVIEW

The effects that exercise at altitude has on the neurological system are diverse and still not well studied, and range from metabolic adaptations to modification of cerebral blood flow and neurotransmitters. In this review we summarise changes with exercise intensity, the implications of ascent, cognitive impairment, psychosis-like symptoms, the role of exercise in the development and prevention of AMS, and use of free radical scavengers to enhance sports performance and acclimatization.

RECENT FINDINGS

We discuss the impact of oxidative stress in hypobaric hypoxia and reactive oxygen species (ROS) production and its consequences, with special focus on exercise at altitude. Finally we consider how moderate intensity exercise could help prevent AMS, and the necessity of research on high intensity exercise with elevated rate of ascent, the development of specific tools of cognitive assessment, and the role of free-radical scavengers in the prevention of AMS and neurological symptoms.

摘要

综述目的

在高原进行运动对神经系统的影响是多方面的,且尚未得到充分研究,其影响范围从代谢适应到脑血流和神经递质的改变。在本综述中,我们总结了运动强度变化、海拔上升的影响、认知障碍、类精神病症状、运动在急性高山病(AMS)发生和预防中的作用,以及使用自由基清除剂提高运动表现和促进适应的相关情况。

最新发现

我们讨论了低压低氧环境下氧化应激和活性氧(ROS)产生的影响及其后果,特别关注高原运动。最后,我们考虑中等强度运动如何有助于预防AMS,以及对上升速度加快的高强度运动、特定认知评估工具的开发,以及自由基清除剂在预防AMS和神经症状方面的作用进行研究的必要性。

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