Jaeckle R S, Nasrallah H A
J Nerv Ment Dis. 1985 Aug;173(8):503-8. doi: 10.1097/00005053-198508000-00009.
A case of major depressive disorder complicated by carbon monoxide (CO)-induced Parkinson's syndrome is reported. Computerized axial tomography (CAT) revealed bilateral globus pallidus necrosis. Clinical, CAT, and neuropathological findings in other cases of CO encephalopathy with and without parkinsonism are reviewed. The utility of CAT in the diagnostic workup and in following clinical course is discussed, as are the difficulties of making a diagnosis of an antecedent primary psychiatric disorder in the presence of neurological and psychiatric sequelae of CO intoxication. There was no clinical response to a tricyclic antidepressant, but both the mood and movement disorders responded fully to L-dopa. The implications of these findings with regard to the central neurochemical pathophysiology in this patient and in major depressive disorder in general are discussed.
报告了1例伴有一氧化碳（CO）诱发帕金森综合征的重度抑郁症病例。计算机断层扫描（CAT）显示双侧苍白球坏死。对其他有或无帕金森症的CO脑病病例的临床、CAT及神经病理学发现进行了回顾。讨论了CAT在诊断检查及跟踪临床病程中的作用，以及在存在CO中毒的神经和精神后遗症时诊断先前原发性精神障碍的困难。三环类抗抑郁药无临床疗效，但情绪和运动障碍对左旋多巴均有完全反应。讨论了这些发现对该患者及一般重度抑郁症患者中枢神经化学病理生理学的意义。
