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在低收入和中等收入国家,什么措施对减少发育迟缓有效?全球发育迟缓示范项目的累积经验教训。

What works for reducing stunting in low-income and middle-income countries? Cumulative learnings from the Global Stunting Exemplars Project.

作者信息

Bhutta Zulfiqar A, Islam Muhammad, Gaffey Michelle F, Victora Cesar G, Menon Purnima, Katz Joanne, Horton Susan E, Yearwood Jamal, Black Robert E

机构信息

Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Institute for Global Health and Development, Aga Khan University, Karachi, Pakistan.

Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.

出版信息

Am J Clin Nutr. 2025 Apr;121 Suppl 1:S113-S128. doi: 10.1016/j.ajcnut.2025.03.004.

Abstract

BACKGROUND

Impaired linear growth and stunting in children under 5 y is a marker of multiple deprivations in low-income and middle-income countries.

OBJECTIVES

We aimed to assess drivers and policies influencing improvements in linear growth and stunting reduction in 10 countries with annual rates of reduction in childhood stunting averaging 1.1% (range: 0.4%-1.7%) at national-level or subnational-level, and to improve a framework of action for other countries to follow.

METHODS

We used mixed methods to assess trends and patterns of improvement in linear growth in children under 5 y using available household-level data and in-depth analysis of programs and their implementation. We assessed patterns of change with multivariate regression analyses of risk factors driving stunting and affecting change. We compared results from the Oaxaca-Blinder decomposition analyses using a hierarchical approach and retrospectively assessed the appropriateness of a previously proposed 10-step process for country-level planning and implementation processes. Limited data precluded robust serial assessment of dietary intake at individual level for children and mothers.

RESULTS

Rapid reduction in childhood stunting is possible and findings across exemplar countries underscore the benefits of indirect and direct interventions in health and other social sectors. These include programs focusing on poverty alleviation; water, sanitation, and hygiene; promotion of girls' education and empowerment; and maternal nutrition. The potential benefits of family planning programs and factors contributing to gains in maternal nutrition were noted. In malarial endemic areas, malaria control programs were associated with improved childhood growth, and patterns of growth indicated continued benefits of childhood disease prevention and management strategies.

CONCLUSIONS

A systematic, evidence-informed approach to improve maternal and child health and nutrition is feasible and, with targeting, can accelerate reduction in linear growth faltering in childhood.

摘要

背景

5岁以下儿童线性生长受损和发育迟缓是低收入和中等收入国家多种贫困状况的一个标志。

目的

我们旨在评估影响10个国家线性生长改善和发育迟缓减少的驱动因素及政策,这些国家在国家或次国家层面儿童发育迟缓的年减少率平均为1.1%(范围:0.4%-1.7%),并完善一个供其他国家遵循的行动框架。

方法

我们采用混合方法,利用现有的家庭层面数据以及对项目及其实施情况的深入分析,评估5岁以下儿童线性生长改善的趋势和模式。我们通过对导致发育迟缓和影响变化的风险因素进行多变量回归分析来评估变化模式。我们使用分层方法比较了瓦哈卡-布林德分解分析的结果,并回顾性评估了先前提出的用于国家层面规划和实施过程的10步流程的适用性。有限的数据妨碍了对儿童和母亲个体层面饮食摄入量进行有力的连续评估。

结果

儿童发育迟缓的快速减少是可能的,各示范国家的研究结果强调了在卫生和其他社会部门进行间接和直接干预的益处。这些干预包括侧重于扶贫、水、环境卫生和个人卫生、促进女童教育和赋权以及孕产妇营养的项目。我们注意到计划生育项目的潜在益处以及有助于孕产妇营养改善的因素。在疟疾流行地区,疟疾控制项目与儿童生长改善相关,生长模式表明儿童疾病预防和管理策略持续发挥着作用。

结论

一种系统的、基于证据的改善母婴健康和营养的方法是可行的,并且通过有针对性的实施,可以加速减少儿童期线性生长发育迟缓。

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