Liu Pei, An Guangqi, Lu Chenyu, Li Shu, Chen Haoxiang, Jin Bo, Du Liping, Jin Xuemin
Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, China.
Henan Eye Hospital, Zhengzhou, 450000, China.
Sci Rep. 2025 Apr 9;15(1):12187. doi: 10.1038/s41598-025-95561-2.
To analyze the epidemiology, clinical features, and Swept-Source Optical Coherence Tomography findings in patients with Focal Choroidal Excavation. 97 patients with FCE were identified from 50,000 scans of 25,000 individuals who underwent SS-OCT examinations. These patients' clinical and imaging features were recorded, while data from 37 individuals with follow-up records were analyzed. FCE lesions were classified into three subtypes: (1) type 1: leptochoroid type (SFCT: <100 μm), (2) type 2: normochoroid type (SFCT: 100-200 μm), and (3) type 3: pachychoroid type (SFCT: >200 μm). A total of 108 FCEs were identified in 100 eyes, with 66 (61.1%) classified as Conforming type and 42 (38.9%) as non-conforming type. The maximum depth of FCEs in the study cohort was 96.6 ± 78.4 μm, the maximum width was 875.1 ± 960.1 μm, and choroidal thickness under FCE was 200.5 ± 191.5 μm. We observed 10 chorioretinopathy coexisting with FCE and categorized FCE based on choroidal thickness, highlighting three distinct types associated with different chorioretinopathy. Follow-up assessments revealed the relative stability of FCE and the efficacy of Anti-VEGF treatment for FCE-related CNV. Choroidal thickness playing a role in determining the specific type of FCE when combined with chorioretinopathy. Factors such as choroidal inflammation, scarring, and abnormal dilation of choroidal blood vessels may contribute to the damage or loss of outer retinal and inner choroidal tissues in FCE cases. FCE typically demonstrates stability over time, and Anti-VEGF treatment has shown efficacy in managing FCE-related CNV.
分析局灶性脉络膜凹陷患者的流行病学、临床特征及扫频光学相干断层扫描结果。从25000例接受扫频光学相干断层扫描（SS-OCT）检查的个体的50000次扫描中识别出97例局灶性脉络膜凹陷（FCE）患者。记录这些患者的临床和影像学特征，并分析37例有随访记录个体的数据。FCE病变分为三种亚型：（1）1型：薄脉络膜型（SFCT：<100μm），（2）2型：正常脉络膜型（SFCT：100 - 200μm），（3）3型：厚脉络膜型（SFCT：>200μm）。在100只眼中共识别出108处FCE，其中66处（61.1%）为符合型，42处（38.9%）为不符合型。研究队列中FCE的最大深度为96.6±78.4μm，最大宽度为875.1±960.1μm，FCE下方的脉络膜厚度为200.5±191.5μm。我们观察到10例FCE合并脉络膜视网膜病变，并根据脉络膜厚度对FCE进行分类，突出了与不同脉络膜视网膜病变相关的三种不同类型。随访评估显示FCE相对稳定，抗血管内皮生长因子（Anti-VEGF）治疗对FCE相关脉络膜新生血管（CNV）有效。当与脉络膜视网膜病变合并时，脉络膜厚度在确定FCE的具体类型中起作用。脉络膜炎症、瘢痕形成和脉络膜血管异常扩张等因素可能导致FCE病例中外层视网膜和内层脉络膜组织的损伤或丧失。FCE通常随时间表现出稳定性，抗VEGF治疗已显示出对治疗FCE相关CNV有效。
