Baksa Daniel, Eszlari Nora, Torok Dora, Hullam Gabor, Bagdy Gyorgy, Juhasz Gabriella
Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences, Semmelweis University, Budapest, Hungary.
NAP3.0-SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.
J Sleep Res. 2025 Oct;34(5):e70066. doi: 10.1111/jsr.70066. Epub 2025 Apr 10.
Migraine has been linked to chronotype, but with mixed results. Here, we tested chronotype in association with physical and mental health and headache characteristics in a large database of migraine patients and controls. A sample of the UK Biobank (n = 360,081; 58.3% female, mean age: 56.38) was used. Data included self-reported chronotype, mental (neuroticism, depression, stress) and physical (body fat percentage, overall health rating) health factors, and migraine diagnosis based on ICD-10 G43 diagnosis from healthcare data. Morning type controls (C , n = 210,775), evening type controls (C , n = 129,174), morning type migraine patients (M , n = 12,194), and evening type migraine patients (M , n = 7938) were compared. Additionally, in a subsample of questionnaire-based migraine (n = 15,356), chronotype was tested in association with headache-related features. One-way ANOVA, Kruskal-Wallis test and chi-squared test were run in SPSS 28 with Bonferroni correction. Evening chronotype was more frequent among migraine patients with an OR = 1.06, 95% CI [1.03; 1.09] compared to controls (χ = 16.523, p < 0.001). The M group showed the worst level of all mental and physical health variables, while the C group reported the best values. Migraine patients with morning or evening chronotype showed a highly similar headache symptom profile, but the M subgroup expressed a higher disability (t = -3.965, p < 0.001). In conclusion, evening chronotype was associated with the worst physical and mental health status and the highest headache-related disability among migraine patients, suggesting a need for elevated medical attention on chronotype in migraine.
偏头痛与昼夜节律类型有关，但结果不一。在此，我们在一个包含大量偏头痛患者和对照的数据库中，测试了昼夜节律类型与身心健康及头痛特征之间的关系。使用了英国生物银行的一个样本（n = 360,081；58.3%为女性，平均年龄：56.38岁）。数据包括自我报告的昼夜节律类型、心理（神经质、抑郁、压力）和身体（体脂百分比、总体健康评分）健康因素，以及基于医疗保健数据中ICD - 10 G43诊断的偏头痛诊断。比较了晨型对照（C ，n = 210,775）、夜型对照（C ，n = 129,174）、晨型偏头痛患者（M ，n = 12,194）和夜型偏头痛患者（M ，n = 7938）。此外，在一个基于问卷的偏头痛子样本（n = 15,356）中，测试了昼夜节律类型与头痛相关特征之间的关系。在SPSS 28中进行了单因素方差分析、Kruskal - Wallis检验和卡方检验，并进行了Bonferroni校正。与对照相比，偏头痛患者中夜型昼夜节律类型更为常见，OR = 1.06，95% CI [1.03；1.09]（χ = 16.523，p < 0.001）。M 组在所有心理和身体健康变量方面表现出最差水平，而C 组报告的数值最佳。晨型或夜型昼夜节律类型的偏头痛患者表现出高度相似的头痛症状特征，但M 亚组表现出更高的残疾程度（t = -3.965，p < 0.001）。总之，夜型昼夜节律类型与偏头痛患者中最差的身心健康状况以及与头痛相关的最高残疾程度相关，这表明在偏头痛中需要提高对昼夜节律类型的医疗关注。
