Li Yi, Zang Yi-Tong, Tong Wei-Dong
Division of Gastric and Colorectal, Department of General Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Department of Medical imaging, the Thirteenth People's Hospital of Chongqing, Chongqing, China.
J Neurogastroenterol Motil. 2025 Apr 30;31(2):256-266. doi: 10.5056/jnm23181.
BACKGROUND/AIMS: The association between caffeine intake and constipation remains inconclusive. This study aims to investigate whether caffeine intake is associated with constipation.
This cross-sectional study included 13 941 adults from the 2005-2010 National Health and Nutrition Examination Survey. The weighted logistic regression analyses were exerted to evaluate the association between caffeine intake and constipation. Besides, stratified analyses and interaction tests were conducted to determine the potential modifying factors.
After adjusting for confounders, increased caffeine intake by 100 mg was not associated with constipation, as defined by stool frequency (OR, 1.01; 95% CI, 0.94-1.10) or stool consistency (OR, 1.01; 95% CI, 0.98-1.05). Subgroup analyses showed that cholesterol intake modified the relationship between increased caffeine by 100 mg and stool frequency-defined constipation ( for interaction = 0.037). Each 100 mg increase in caffeine intake was associated with a 20% decreased risk of constipation defined by stool frequency in participants who consumed high cholesterol (OR, 0.80; 95% CI, 0.64-1.00), but no association in the other 2 cholesterol level groups. Furthermore, the association between caffeine intake and stool consistency-defined constipation was not found in different cholesterol groups.
Caffeine consumption is not associated with stool frequency or consistency-defined constipation. Nevertheless, increased caffeine intake may decrease the risk of constipation (defined by stool frequency) among participants in the high-cholesterol intake group.
背景/目的：咖啡因摄入量与便秘之间的关联尚无定论。本研究旨在调查咖啡因摄入量是否与便秘有关。
这项横断面研究纳入了2005 - 2010年国家健康与营养检查调查中的13941名成年人。采用加权逻辑回归分析来评估咖啡因摄入量与便秘之间的关联。此外，进行了分层分析和交互作用检验以确定潜在的修正因素。
在调整混杂因素后，咖啡因摄入量每增加100毫克与便秘无关，便秘定义为排便频率（比值比[OR]，1.01；95%置信区间[CI]，0.94 - 1.10）或粪便稠度（OR，1.01；95% CI，0.98 - 1.05）。亚组分析表明，胆固醇摄入量改变了咖啡因摄入量增加100毫克与排便频率定义的便秘之间的关系（交互作用P = 0.037）。在高胆固醇摄入的参与者中，咖啡因摄入量每增加100毫克，排便频率定义的便秘风险降低20%（OR，0.80；95% CI，0.64 - 1.00），但在其他两个胆固醇水平组中无关联。此外，在不同胆固醇组中未发现咖啡因摄入量与粪便稠度定义的便秘之间的关联。
饮用咖啡因与排便频率或粪便稠度定义的便秘无关。然而，增加咖啡因摄入量可能会降低高胆固醇摄入组参与者便秘（由排便频率定义）的风险。
