School of Medicine and Institute of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, 402, Taiwan.
Int J Colorectal Dis. 2022 Mar;37(3):623-630. doi: 10.1007/s00384-021-04086-3. Epub 2022 Jan 6.
Postoperative ileus (POI) is the most common complication of elective colon resection. Coffee or caffeine has been reported to be useful in improving gastrointestinal function after abdominal surgery. This study aimed to investigate the effect of coffee/caffeine on POI in patients undergoing elective colorectal surgery.
We searched Cochrane library, Embase, PubMed, and ClinicalTrials.gov (until July 2021) to identify randomized controlled trials (RCTs) evaluating the effect of coffee or caffeine on bowel movements and POI in patients undergoing elective colorectal surgery. The mean difference (MD) for continuous outcomes and risk ratio (RR) for dichotomous outcomes were calculated and are presented with 95% confidence intervals (CIs). A random effects model was used in all meta-analyses.
A total of four RCTs including 312 subjects met the inclusion criteria and were included in the meta-analysis. Postoperative coffee or caffeine consumption decreased the time to first bowel movement (MD, - 10.36 h; 95% CI, - 14.61 to - 6.11), shortened the length of hospital stay (MD, - 0.95 days; 95% CI, - 1.57 to - 0.34), and was associated with a decreased risk of the use of any laxatives after the procedure (RR, 0.64; 95% CI, 0.44 to 0.92). The time to first flatus, time to tolerance of solid food, risk of any postoperative complication, postoperative reinsertion of a nasogastric (NG) tube, and anastomotic leakage showed no statistical differences between groups.
Postoperative coffee or caffeine consumption improved bowel movement and decreased the duration of hospital stay in patients undergoing elective colorectal surgery. This method is safe and can prevent or treat POI.
术后肠麻痹（POI）是择期结肠切除术最常见的并发症。有报道称，咖啡或咖啡因可改善腹部手术后的胃肠道功能。本研究旨在探讨咖啡/咖啡因对择期结直肠手术患者 POI 的影响。
我们检索了 Cochrane 图书馆、Embase、PubMed 和 ClinicalTrials.gov（截至 2021 年 7 月），以确定评估咖啡或咖啡因对择期结直肠手术患者排便和 POI 影响的随机对照试验（RCT）。连续结局的均数差（MD）和二分类结局的风险比（RR）以 95%置信区间（CI）表示。所有荟萃分析均采用随机效应模型。
共有 4 项 RCT 包括 312 例患者符合纳入标准并纳入荟萃分析。术后饮用咖啡或摄入咖啡因可减少首次排便时间（MD，-10.36 h；95%CI，-14.61 至-6.11），缩短住院时间（MD，-0.95 天；95%CI，-1.57 至-0.34），并降低术后使用任何泻药的风险（RR，0.64；95%CI，0.44 至 0.92）。首次排气时间、耐受固体食物时间、任何术后并发症风险、术后再次插入鼻胃管（NG 管）和吻合口漏的风险在组间无统计学差异。
术后饮用咖啡或摄入咖啡因可改善择期结直肠手术患者的肠蠕动，并缩短住院时间。这种方法安全有效，可预防或治疗 POI。
