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Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis.

作者信息

Cai Yuee, Guan Zhangyan, Tong Yin, Zhao Weiyang, Zhang Jiangwen, Peng Ling, Ip Philip P C, To Sally K Y, Wong Alice S T

机构信息

School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.

Department of Pathology, School of Clinical Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China.

出版信息

Protein Cell. 2025 Jul 19;16(7):602-608. doi: 10.1093/procel/pwaf019.

DOI:10.1093/procel/pwaf019
PMID:40205990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12275092/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9acc/12275092/96ff3ad0d227/pwaf019_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9acc/12275092/2df036c2eb08/pwaf019_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9acc/12275092/96ff3ad0d227/pwaf019_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9acc/12275092/2df036c2eb08/pwaf019_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9acc/12275092/96ff3ad0d227/pwaf019_fig2.jpg

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本文引用的文献

1
P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis.P-钙黏蛋白通过机械激活肿瘤-间皮代谢偶联来促进卵巢癌转移。
Cell Rep. 2025 Jan 28;44(1):115096. doi: 10.1016/j.celrep.2024.115096. Epub 2024 Dec 18.
2
Endocytosis in cancer and cancer therapy.癌症和癌症治疗中的内吞作用。
Nat Rev Cancer. 2023 Jul;23(7):450-473. doi: 10.1038/s41568-023-00574-6. Epub 2023 May 22.
3
Metastasis.转移。
Cell. 2023 Apr 13;186(8):1564-1579. doi: 10.1016/j.cell.2023.03.003.
4
HDAC9 Contributes to Serous Ovarian Cancer Progression through Regulating Epithelial-Mesenchymal Transition.组蛋白去乙酰化酶9通过调控上皮-间质转化促进浆液性卵巢癌进展。
Biomedicines. 2022 Feb 3;10(2):374. doi: 10.3390/biomedicines10020374.
5
Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis.瞬时细胞命运遗传命运图谱揭示 N-钙黏蛋白在肿瘤转移中的活性和功能。
Dev Cell. 2020 Sep 14;54(5):593-607.e5. doi: 10.1016/j.devcel.2020.06.021. Epub 2020 Jul 14.
6
The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance.上皮-间质可塑性在卵巢癌进展和治疗耐药中的作用
Cancers (Basel). 2019 Jun 17;11(6):838. doi: 10.3390/cancers11060838.
7
Ovarian cancer cell lines derived from non-serous carcinomas migrate and invade more aggressively than those derived from high-grade serous carcinomas.来源于非浆液性癌的卵巢癌细胞系比来源于高级别浆液性癌的细胞系迁移和侵袭能力更强。
Sci Rep. 2019 Apr 2;9(1):5515. doi: 10.1038/s41598-019-41941-4.
8
N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer.N-钙黏蛋白在癌症转移中的作用、其在血液系统恶性肿瘤中日益凸显的作用以及作为癌症治疗靶点的潜力。
BMC Cancer. 2018 Oct 1;18(1):939. doi: 10.1186/s12885-018-4845-0.
9
MR4Cancer: a web server prioritizing master regulators for cancer.MR4Cancer：一个优先考虑癌症主调控因子的网络服务器。
Bioinformatics. 2019 Feb 15;35(4):636-642. doi: 10.1093/bioinformatics/bty658.
10
EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration.EMT 亚型影响上皮细胞的可塑性和细胞迁移方式。
Dev Cell. 2018 Jun 18;45(6):681-695.e4. doi: 10.1016/j.devcel.2018.05.027.