Shah Bulle, Singh Narinder, Jang Doo Ok
Department of Chemistry, Indian Institute of Technology Ropar Rupnagar Punjab 140001 India
Department of Chemistry, Yonsei University Wonju 26493 Republic of Korea
RSC Adv. 2025 Apr 9;15(14):11215-11229. doi: 10.1039/d5ra00236b. eCollection 2025 Apr 4.
A multicomponent Biginelli reaction was used to produce biologically active dihydropyrimidones that were then combined with ZnO nanoparticles. Biginelli compounds synthesized with various alkyl chains were characterized using high-resolution mass spectrometry as well as H- and C-NMR spectroscopy. Efficient antibacterial gels were developed by introducing the prepared Biginelli compounds and ZnO nanoparticles into a carbomer polymer matrix. Antibacterial screening revealed that the ABS-G4 gel exhibited the highest antibacterial potential, with minimum inhibitory concentrations of 16 ± 2 and 12 ± 2 μg mL against and , respectively. The ABS-G4 gel was characterized using rheological studies, field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, powder X-ray diffraction, and atomic force microscopy. The ABS-G4 gel was showing more antibacterial efficacy toward Gram-positive strains of bacteria than Gram-positive ones. An antibacterial dressing was formed by coating the developed gel onto a gauze dressing.
采用多组分Biginelli反应制备具有生物活性的二氢嘧啶酮，然后将其与ZnO纳米颗粒结合。使用高分辨率质谱以及H-和C-NMR光谱对合成的具有各种烷基链的Biginelli化合物进行了表征。通过将制备的Biginelli化合物和ZnO纳米颗粒引入卡波姆聚合物基质中，开发出了高效抗菌凝胶。抗菌筛选表明，ABS-G4凝胶表现出最高的抗菌潜力，对金黄色葡萄球菌和大肠杆菌的最低抑菌浓度分别为16±2和12±2μg/mL。使用流变学研究、场发射扫描电子显微镜、能量色散X射线光谱、粉末X射线衍射和原子力显微镜对ABS-G4凝胶进行了表征。ABS-G4凝胶对革兰氏阳性菌的抗菌效果比对革兰氏阴性菌更好。通过将开发的凝胶涂覆在纱布敷料上形成了抗菌敷料。
