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全球首例82岁劈离式肝移植受者:病例报告

An 82-year-old recipient of split liver transplantation worldwide: A case report.

作者信息

Feng Xiao, Fu Binsheng, Yang Qing, Zeng Kaining, Yi Huimin, Yi Shuhong, Yang Yang

机构信息

Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Surgical Intensive Care Unit, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

出版信息

Liver Res. 2025 Jan 4;9(1):74-78. doi: 10.1016/j.livres.2024.12.004. eCollection 2025 Mar.

DOI:10.1016/j.livres.2024.12.004
PMID:40206436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11977115/
Abstract

Split liver transplantation (SLT) has become an indispensable method for expanding the donor liver pool. However, advanced age in recipients can have significant adverse effects on prognosis. We report the case of an 82-year-old man with chronic liver failure and polycystic liver disease who underwent split right triple lobe donor liver transplantation on October 29, 2021. The patient made a remarkable recovery and was discharged 1 month after surgery. To date, he has been followed up for 32 months, with favorable laboratory and imaging test results, and no significant abnormalities or complications. Currently, this patient may be the oldest SLT recipient in the world. With comprehensive preoperative evaluation, optimized surgical techniques, and individually tailored postoperative care, older adults can safely undergo SLT. Therefore, advanced age should not be considered an absolute contraindication for this procedure.

摘要

劈离式肝移植(SLT)已成为扩大供肝来源不可或缺的方法。然而,受者年龄较大可能对预后产生重大不利影响。我们报告一例82岁男性慢性肝衰竭合并多囊肝疾病患者,于2021年10月29日接受了劈离式右三叶供肝移植。患者术后恢复良好,术后1个月出院。迄今为止,他已接受了32个月的随访,实验室检查和影像学检查结果良好,无明显异常或并发症。目前,该患者可能是世界上接受劈离式肝移植年龄最大的受者。通过全面的术前评估、优化的手术技术和个体化的术后护理,老年人可以安全地接受劈离式肝移植。因此,高龄不应被视为该手术的绝对禁忌证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/ac2d32dcf206/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/85b7bee95743/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/2cf2f13c6e16/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/3226b7e8dc14/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/6c1f378b5ca0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/d4e455fef828/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/ac2d32dcf206/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/85b7bee95743/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/2cf2f13c6e16/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/3226b7e8dc14/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/6c1f378b5ca0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/d4e455fef828/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4406/11977115/ac2d32dcf206/gr6.jpg

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本文引用的文献

1
Chinese expert consensus on evaluation of donor and donor liver for split liver transplantation.中国劈离式肝移植供体及供肝评估专家共识
Liver Res. 2022 Apr 21;6(2):59-65. doi: 10.1016/j.livres.2022.03.002. eCollection 2022 Jun.
2
Addressing the challenges of split liver transplantation through technical advances. A systematic review.通过技术进步解决劈离式肝移植的挑战。系统评价。
Transplant Rev (Orlando). 2021 Jul;35(3):100627. doi: 10.1016/j.trre.2021.100627. Epub 2021 May 19.
3
Evolving Role of Liver Transplantation in Elderly Recipients.
肝移植在老年受者中的作用演变。
Liver Transpl. 2019 Sep;25(9):1363-1374. doi: 10.1002/lt.25589. Epub 2019 Jul 20.
4
Split liver transplantation: Current developments.劈离式肝移植:现状与进展。
World J Gastroenterol. 2018 Dec 21;24(47):5312-5321. doi: 10.3748/wjg.v24.i47.5312.
5
Age and liver transplantation.年龄与肝移植。
J Hepatol. 2019 Apr;70(4):745-758. doi: 10.1016/j.jhep.2018.12.009. Epub 2018 Dec 18.
6
Liver Transplantation Today: Where We Are Now and Where We Are Going.肝脏移植的今天:我们现在在哪里,以及我们要去哪里。
Liver Transpl. 2018 Oct;24(10):1470-1475. doi: 10.1002/lt.25320.
7
Recipient characteristics and morbidity and mortality after liver transplantation.肝移植受者的特征与发病率和死亡率。
J Hepatol. 2018 Jul;69(1):43-50. doi: 10.1016/j.jhep.2018.02.004. Epub 2018 Feb 15.
8
Usefulness of Liver Transplantation in the Elderly: The Converging Impact of Risk and Benefit.肝移植在老年人中的效用:风险与益处的综合影响
Gastroenterology. 2016 Feb;150(2):306-9. doi: 10.1053/j.gastro.2015.12.020. Epub 2015 Dec 19.
9
Aging of Liver Transplant Registrants and Recipients: Trends and Impact on Waitlist Outcomes, Post-Transplantation Outcomes, and Transplant-Related Survival Benefit.肝移植登记和受者的老龄化:趋势及其对等待名单结局、移植后结局和移植相关生存获益的影响。
Gastroenterology. 2016 Feb;150(2):441-53.e6; quiz e16. doi: 10.1053/j.gastro.2015.10.043. Epub 2015 Oct 30.
10
Evaluation for liver transplantation in adults: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation.成人肝移植评估:美国肝病研究协会和美国移植学会2013年实践指南
Hepatology. 2014 Mar;59(3):1144-65. doi: 10.1002/hep.26972.