Yang Hua, Wang Qianyao, Li Min, Yu Jin, Li Hua, Zhang Shufeng, Qian Hairong
Department of Neurology, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China.
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People's Republic of China.
Int J Gen Med. 2025 Apr 5;18:1969-1981. doi: 10.2147/IJGM.S502460. eCollection 2025.
To investigate the relationship between blood pressure variability (BPV) and serum vascular endothelial growth factor (VEGF) levels in patients with type I cerebral small vessel disease (CSVD).
144 Patients admitted to the Neurology Department of our Hospital between December 2021 and December 2022 were included and categorized into 5 groups according to CSVD burden, which was evaluated based on MRI findings. Group 0-2 were categorized as mild patients, group 3 as moderate patients, group 4 as severe patients. All patients underwent 24-hour ambulatory blood pressure monitoring. Serum samples were collected to measure the concentration of VEGF. The differences of general information, BPV and serum VEGF levels in five groups were compared. Spearman correlation analysis was used to analyze the correlation between total CSVD burden and BPV, as well as total CSVD burden and serum VEGF concentration. Additionally, Pearson correlation analysis was used to explore the correlation between serum VEGF level and BPV.
83 males and 61 females with mean age of (67.5±9.9) years were enrolled. Significant differences were observed in age and hypertension history among the five groups (p<0.001). In both mild and severe groups, 24hSBP, 24hSBP-SD, 24hSBP-CV, 24hSBP-ARV, DSBP, DSBP-SD, DSBP-ARV, 24hDBP, 24hDBP-SD, DDBP, NDBP showed a significant positive correlation with the total CSVD burden scores. The differences in serum VEGF concentration among the five groups were statistically significant (P<0.05), with the lowest in group 4 and the highest in group 3. Serum VEGF concentration showed a significant positive correlation with the total CSVD burden scores in patients with mild to moderate CSVD. Pearson's correlation analysis revealed that serum VEGF concentration was significantly and positively correlated with 24hSBP-SD, 24hSBP- ARV, DSBP-SD, DSBP-ARV, and SBP-wSD.
VEGF may be associated with the impact of BPV on CSVD patients, and potentially correlated to delaying disease progression.
探讨I型脑小血管病（CSVD）患者血压变异性（BPV）与血清血管内皮生长因子（VEGF）水平之间的关系。
纳入2021年12月至2022年12月期间在我院神经内科住院的144例患者，根据基于MRI结果评估的CSVD负担将其分为5组。0 - 2组为轻症患者，3组为中度患者，4组为重度患者。所有患者均接受24小时动态血压监测。采集血清样本以测量VEGF浓度。比较五组患者的一般信息、BPV和血清VEGF水平的差异。采用Spearman相关性分析来分析总CSVD负担与BPV之间的相关性，以及总CSVD负担与血清VEGF浓度之间的相关性。此外，采用Pearson相关性分析来探讨血清VEGF水平与BPV之间的相关性。
共纳入83例男性和61例女性，平均年龄为（67.5±9.9）岁。五组患者在年龄和高血压病史方面存在显著差异（p<0.001）。在轻症和重症组中，24小时收缩压（24hSBP）、24小时收缩压标准差（24hSBP-SD）、24小时收缩压变异系数（24hSBP-CV）、24小时收缩压平均实际波动幅度（24hSBP-ARV）、日间收缩压（DSBP）、日间收缩压标准差（DSBP-SD）、日间收缩压平均实际波动幅度（DSBP-ARV）以及24小时舒张压（24hDBP）、24小时舒张压标准差（24hDBP-SD）、夜间舒张压（DDBP）、夜间舒张压标准差（NDBP）均与总CSVD负担评分呈显著正相关。五组患者血清VEGF浓度差异具有统计学意义（P<0.05），4组最低，3组最高。在轻度至中度CSVD患者中，血清VEGF浓度与总CSVD负担评分呈显著正相关。Pearson相关性分析显示，血清VEGF浓度与24hSBP-SD、24hSBP-ARV、DSBP-SD、DSBP-ARV以及收缩压加权标准差（SBP-wSD）呈显著正相关。
VEGF可能与BPV对CSVD患者的影响有关，并可能与延缓疾病进展相关。
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