Large J, Tyler K R
J Physiol. 1985 May;362:13-21. doi: 10.1113/jphysiol.1985.sp015659.
The recovery of muscle weight and contraction tension was measured in rat anterior tibialis muscle following unilateral crushing of the lateral popliteal nerve. Muscle twitch and tetanic tensions and muscle weight had recovered to control values within 6-8 weeks after the nerve was crushed. Capillary supply to each of the four types of muscle fibre present in the intact muscle, and within the groups of adjacent fibres of similar histochemical reaction for succinate dehydrogenase and myofibrillar actomyosin ATPase found in the reinnervated muscle, was computed by the method of Gray & Renkin (1978). Capillary area density (capillaries/mm2) within the grouped regions of the reinnervated muscle was not significantly different from the supply to the same fibre type in intact contralateral muscles. Capillary/fibre ratio for the more glycolytic fibre types (alpha W, alpha?) was lower than in intact muscle, while the values for both alpha R and beta R oxidative fibres agreed closely with control values. It seems that selective growth and loss of capillaries occurs during reinnervation, adjusting capillary supply to meet the changed metabolic demands of the individual fibres following regrouping.
在大鼠胫前肌外侧腘神经单侧挤压后，测量肌肉重量和收缩张力的恢复情况。神经挤压后6 - 8周内，肌肉抽搐和强直张力以及肌肉重量已恢复至对照值。通过Gray和Renkin（1978年）的方法，计算了完整肌肉中存在的四种肌纤维类型以及在重新支配的肌肉中发现的琥珀酸脱氢酶和肌原纤维肌动球蛋白ATP酶具有相似组织化学反应的相邻纤维组内的毛细血管供应。重新支配的肌肉分组区域内的毛细血管面积密度（毛细血管/mm²）与完整对侧肌肉中相同纤维类型的供应情况无显著差异。糖酵解能力较强的纤维类型（αW、α?）的毛细血管/纤维比值低于完整肌肉，而αR和βR氧化纤维的比值与对照值非常接近。似乎在重新支配过程中发生了毛细血管的选择性生长和丧失，从而调整毛细血管供应以满足重新分组后各纤维代谢需求的变化。
