Li Qing, Xu Chen-Sen, Yu Hao-Lin, Zhang Yu, Wang Jin, Shen Yi-Bo, Wu Hong-Wei, Gu Min-Min, Liao Zhi-Xin
Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering and Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China.
Nutrition Department, First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, PR China.
Org Lett. 2025 Apr 25;27(16):4300-4304. doi: 10.1021/acs.orglett.5c00953. Epub 2025 Apr 10.
Lauicyclone A (), a new skeletal diterpenoid characterized by an unprecedented carbon skeleton, represents the first reported natural product featuring a complex tricyclo[4.3.1]decane framework. Along with Lauicyclones B-E (-), all five compounds were isolated from . Comprehensive spectroscopic analyses, quantum-chemical calculations, and X-ray diffractions were used to identify their structures. The antitumor mechanism of compound was investigated using H NMR-based metabolomics.
劳伊西克隆A（）是一种具有前所未有的碳骨架的新型骨架二萜，是首个报道的具有复杂三环[4.3.1]癸烷骨架的天然产物。与劳伊西克隆B - E（-）一起，这五种化合物均从……中分离得到。采用综合光谱分析、量子化学计算和X射线衍射来确定它们的结构。使用基于1H NMR的代谢组学研究了化合物……的抗肿瘤机制。
