State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
J Nat Prod. 2014 Apr 25;77(4):1013-20. doi: 10.1021/np500042c. Epub 2014 Apr 15.
Fourteen new diterpenoids including clerodane (1-12), labdane (13), and norlabdane (14) types, as well as nine known analogues were isolated from the aerial parts of Croton laui. Their structures were established on the basis of spectroscopic analysis, and that of crotonolide H (11) was confirmed by single-crystal X-ray crystallography. Crotonolide A (1) exhibited moderate cytotoxicity against two tumor cell lines, HL-60 (human premyelocytic leukemia, IC50 9.42 μM) and P-388 (murine leukemia, IC50 7.45 μM), and crotonolide G (10) displayed significant antibacterial activity against a panel of Gram-positive bacteria.
从拉威克罗顿中分离得到 14 个新的二萜类化合物，包括 clerodane（1-12）、labdane（13）和 norlabdane（14）型，以及 9 个已知类似物。它们的结构是基于光谱分析确定的，其中 crotonolide H（11）的结构通过单晶 X 射线晶体学确定。克罗通内酯 A（1）对两种肿瘤细胞系 HL-60（人早幼粒细胞白血病，IC50 9.42 μM）和 P-388（鼠白血病，IC50 7.45 μM）表现出中等的细胞毒性，而克罗通内酯 G（10）对一系列革兰氏阳性菌表现出显著的抗菌活性。
