Starks G C, Grimes E M
J Reprod Med. 1985 Jun;30(6):481-4.
Clinical findings in a group of infertile patients with endometriosis were reviewed to determine if minimal (focal) disease exerted an effect on reproductive outcome. Focal disease, defined as isolated implants less than or equal to 5 mm without pelvic adhesions or anatomic distortion, was found in 69 patients, with 35% manifesting menstrual dysfunction/anovulation. Patients with focal disease were divided into two groups: those treated with danazol (400-800 mg) daily for six months and those not treated. Conception occurred in 71% of the danazol-treated patients and 30% of the untreated ones. These results suggest that focal endometriosis does influence reproductive performance and that infertile patients with focal disease should be treated more aggressively with the available medical regimens, particularly when the infertility is of significant duration or when routine therapy has failed.
回顾了一组患有子宫内膜异位症的不孕患者的临床发现，以确定微小（局灶性）疾病是否会对生殖结局产生影响。局灶性疾病定义为孤立的种植灶小于或等于5mm，无盆腔粘连或解剖结构扭曲，69例患者中发现了局灶性疾病，其中35%表现为月经功能障碍/无排卵。患有局灶性疾病的患者分为两组：一组每天服用达那唑（400 - 800mg），持续六个月；另一组未接受治疗。接受达那唑治疗的患者中有71%受孕，未接受治疗的患者中有30%受孕。这些结果表明，局灶性子宫内膜异位症确实会影响生殖能力，患有局灶性疾病的不孕患者应以现有的药物治疗方案进行更积极的治疗，特别是当不孕持续时间较长或常规治疗失败时。
