Guedea Marc, Sánchez Meritxell, Lozano Alicia, Ferrer Montse, Pont Angels, Clotet Sandra, Juárez Marc, Linares Isabel, Araguas Pablo, Ventura Montse, d'Oliveira Nuno Gustavo, Manzanares Maria Cristina, Ustrell Josep Maria, Guedea Ferran
Orthodontics Department. Facultat de Medicina I Ciències de la Salut, University of Barcelona (UB), Barcelona, Spain.
Radiation Oncology Department, Institut Català d'Oncologia (ICO), Hospital Duran I Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.
Clin Transl Oncol. 2025 Apr 10. doi: 10.1007/s12094-025-03895-0.
Numerous health-related quality of life (HRQoL) questionnaires are available to assess oral HRQoL in patients undergoing treatment for head and neck (H&N) cancer. These multidimensional instruments should have the capacity to detect meaningful clinical oral function/dental changes at different time points. However, the optimal instrument-or combination of instruments-for assessing oral health and dental needs is not clear. We administered three questionnaires (FACT H&N, EORTC QLQ-H&N43, Orthognathic-QLQ) to assess oral and dental HRQoL in a cohort of H&N cancer patients at 1-, 5- and 10-year post-treatment. A secondary aim was to compare these questionnaires to determine which provides the most useful assessment of oral HRQoL and dental care needs.
Prospective, single-center study of patients (n = 82) with H&N cancer grouped according to the follow-up time (1, 5, or 10 years). HRQoL was assessed by telephone with the Functional Assessment of Cancer Therapy (FACT H&N), the European Organization for Research and Treatment (EORTC QLQ-H&N43), and the Orthognathic Questionnaire (OQLQ). Analyses were performed to assess differences between groups.
Eighty-two patients (fifty-nine men) were included. The mean age was 61.9 years. On the EORTC QLQ-H&N43, significant between-group differences (1 year vs. 5 and 10 years) were observed on five multi-item scales (mouth pain, senses, body image, anxiety, and shoulder problems) and on three single-item scales (neurological problems, neck swelling, and weight loss), indicating that QoL for those domains was more negatively impacted at 1-year post-treatment. Adjusted mean scores on most items on the EORTC QLQ-H&N43 were similar in the 5- and 10-year groups. On the other two scales (FACT H&N and OQLG), there were no significant between-group (1, 5, 10 years) differences in adjusted mean scores.
These results show that the negative impact of H&N cancer on HRQoL is most evident at 1-year versus 5- or 10-year post-treatment. The combined administration of the EORTC QLQ-H&N43 and the OQLQ appear to provide the most useful assessment of HRQoL.
有许多与健康相关的生活质量（HRQoL）问卷可用于评估接受头颈部（H&N）癌症治疗患者的口腔HRQoL。这些多维度工具应具备在不同时间点检测有意义的临床口腔功能/牙齿变化的能力。然而，用于评估口腔健康和牙齿需求的最佳工具或工具组合尚不清楚。我们发放了三份问卷（FACT H&N、EORTC QLQ-H&N43、正颌QLQ），以评估一组H&N癌症患者在治疗后1年、5年和10年时的口腔和牙齿HRQoL。第二个目的是比较这些问卷，以确定哪一份问卷能最有效地评估口腔HRQoL和牙齿护理需求。
对H&N癌症患者（n = 82）进行前瞻性单中心研究，根据随访时间（1年、5年或10年）分组。通过电话使用癌症治疗功能评估量表（FACT H&N）、欧洲癌症研究与治疗组织量表（EORTC QLQ-H&N43）和正颌问卷（OQLQ）对HRQoL进行评估。进行分析以评估组间差异。
纳入82例患者（59例男性）。平均年龄为61.9岁。在EORTC QLQ-H&N43量表上，在五个多项目量表（口腔疼痛、感觉、身体形象、焦虑和肩部问题）和三个单项目量表（神经问题颈部肿胀和体重减轻）上观察到显著的组间差异（1年与5年和10年相比），表明这些领域的生活质量在治疗后1年受到的负面影响更大。EORTC QLQ-H&N43量表上大多数项目的调整后平均得分在5年组和10年组中相似。在其他两个量表（FACT H&N和OQLG）上，调整后平均得分在组间（1年、5年、10年）无显著差异。
这些结果表明，H&N癌症对HRQoL的负面影响在治疗后1年比5年或10年时最为明显。联合使用EORTC QLQ-H&N43量表和OQLQ量表似乎能最有效地评估HRQoL。
