用于测试组织工程皮肤的猪模型

Pig Model to Test Tissue Engineered Skin.

作者信息

Tapking Christian, Branski Ludwik K

机构信息

Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Heidelberg, Germany.

Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children® - Galveston, Galveston, TX, USA.

出版信息

Methods Mol Biol. 2025;2922:267-278. doi: 10.1007/978-1-0716-4510-9_20.

DOI:10.1007/978-1-0716-4510-9_20

PMID:40208542

Abstract

Tissue engineering of skin is a field with high research activities and major importance for wound healing, especially following burn injuries. Animal models enable to test tissue engineered skin as well as different types of cells in a realistic setting. Although there are several challenges in working with pigs, it is a good model because of its similarity to the human skin and a comparable wound regeneration. Here, we explain our routinely used methods for using pig models to test tissue engineered skin in burn injuries.

摘要

皮肤组织工程是一个研究活动高度活跃且对伤口愈合，尤其是烧伤后的伤口愈合至关重要的领域。动物模型能够在现实环境中测试组织工程皮肤以及不同类型的细胞。尽管使用猪进行研究存在一些挑战，但由于其与人类皮肤相似且伤口再生情况可比，它仍是一个很好的模型。在此，我们解释我们在烧伤损伤中使用猪模型测试组织工程皮肤的常规方法。