Kremers Sanne H M, Beulens Joline W J, Strikwerda Marije, Remmelzwaal Sharon, Schoonmade Linda J, van der Beek Allard J, Elders Petra J M, Rutters Femke
Department of Epidemiology and Data Science, Amsterdam UMC Location Vrije Universiteit Amsterdam.
University Library, Vrije Universiteit Amsterdam.
Health Psychol. 2025 Oct;44(10):922-935. doi: 10.1037/hea0001498. Epub 2025 Apr 10.
This systematic review and meta-analysis aims to investigate the association of burnout and vital exhaustion (VE) symptoms with (measures of) the metabolic syndrome (MetS).
PubMed, Embase, and PsycINFO were systematically searched until April 26, 2024. Studies investigating adult populations, burnout, or VE as exposures and (measures of) MetS as outcomes were included. Data extraction and quality assessment were performed independently by two observers. If at least three independent effect measures (in at least two studies) were available per association, meta-analyses were performed using random-effects models.
We included 101 studies (71% cross-sectional, 11% case-control, 13% prospective, 5% alternative) comprising 22 strong, 55 moderate, and 24 weak quality studies. Meta-analyses showed relevant but statistically nonsignificant associations of burnout and VE symptoms with higher incident (odds ratio [] = 1.53 [0.82, 2.87], ² = 0%) and prevalent MetS ( = 1.28 [0.99, 1.64], ² = 85%), incident obesity ( = 1.88 [0.81, 4.36], ² = 0%), waist-to-hip ratio (standardized mean difference = 0.62 [-0.65, 1.90], I2 = 95%), prevalent high waist circumference ( = 1.14 [0.80, 1.62], ² = 28%), high triglycerides ( = 1.49 [0.82, 2.71], ² = 40%), and a significantly higher prevalent hypertension (OR = 1.63 [1.44, 1.84], I2 = 51%). We found no clinically relevant associations with remaining MetS measures.
Burnout and VE symptoms might be associated with a higher odds of prevalent and incident MetS, however, not statistically significant. These results should be interpreted with caution due to the cross-sectional design of most studies, use of unadjusted baseline data, and substantial heterogeneity in some analyses. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
本系统评价和荟萃分析旨在研究职业倦怠和倦怠症状与代谢综合征（MetS）（指标）之间的关联。
系统检索了PubMed、Embase和PsycINFO数据库，直至2024年4月26日。纳入了以成年人群、职业倦怠或倦怠症状为暴露因素，以MetS（指标）为结局的研究。由两名观察者独立进行数据提取和质量评估。如果每个关联至少有三项独立效应量（至少两项研究中）可用，则使用随机效应模型进行荟萃分析。
我们纳入了101项研究（71%为横断面研究，11%为病例对照研究，13%为前瞻性研究，5%为其他类型），其中包括22项高质量研究、55项中等质量研究和24项低质量研究。荟萃分析显示，职业倦怠和倦怠症状与更高的新发MetS（优势比[] = 1.53 [0.82, 2.87]，I² = 0%）和现患MetS（ = 1.28 [0.99, 1.64]，I² = 85%）、新发肥胖（ = 1.88 [0.81, 4.36]，I² = 0%）、腰臀比（标准化均数差 = 0.62 [-0.65, 1.90]，I² = 95%）、现患高腰围（ = 1.14 [0.80, 1.62]，I² = 28%）、高甘油三酯（ = 1.49 [0.82, 2.71]，I² = 40%）以及显著更高的现患高血压（优势比 = 1.63 [1.44, 1.84]，I² = 51%）存在相关但无统计学意义的关联。我们未发现与其余MetS指标存在临床相关的关联。
职业倦怠和倦怠症状可能与现患和新发MetS的较高几率相关，但无统计学意义。由于大多数研究的横断面设计、未调整的基线数据使用以及某些分析中存在的大量异质性，这些结果应谨慎解释。（PsycInfo数据库记录（c）2025美国心理学会，保留所有权利）
