-ing the Tide: Gene Therapy Holds Promise for ARVC5.
作者信息
Ratnavadivel Sandra, Ellis Matthew W, Sheikh Farah
机构信息
Department of Medicine, University of California San Diego, La Jolla.
出版信息
Circ Res. 2025 Apr 11;136(8):845-847. doi: 10.1161/CIRCRESAHA.125.326367. Epub 2025 Apr 10.
Abstract
摘要
相似文献
1
-ing the Tide: Gene Therapy Holds Promise for ARVC5.扭转趋势：基因疗法为致心律失常性右室心肌病5型带来希望
Circ Res. 2025 Apr 11;136(8):845-847. doi: 10.1161/CIRCRESAHA.125.326367. Epub 2025 Apr 10.
2
Early Preventive Treatment With Enalapril Improves Cardiac Function and Delays Mortality in Mice With Arrhythmogenic Right Ventricular Cardiomyopathy Type 5.依那普利的早期预防性治疗可改善致心律失常性右室心肌病 5 型小鼠的心脏功能并延迟其死亡。
Circ Heart Fail. 2021 Sep;14(9):e007616. doi: 10.1161/CIRCHEARTFAILURE.120.007616. Epub 2021 Aug 20.
3
Arrhythmogenic Cardiomyopathy: Pathophysiology Beyond Cardiac Myocytes.致心律失常性心肌病：超越心肌细胞的病理生理学
Circ Res. 2017 Dec 8;121(12):1296-1298. doi: 10.1161/CIRCRESAHA.117.312211.
4
The S358L mutation affects cardiac, small intestine, and metabolic homeostasis in a knock-in mouse model.S358L 突变影响 knock-in 小鼠模型中心脏、小肠和代谢稳态。
Am J Physiol Heart Circ Physiol. 2023 Jun 1;324(6):H866-H880. doi: 10.1152/ajpheart.00712.2022. Epub 2023 Apr 21.
5
Overexpression of Wild-Type TMEM43 Improves Cardiac Function in Arrhythmogenic Right Ventricular Cardiomyopathy Type 5.野生型TMEM43的过表达改善5型致心律失常性右室心肌病的心脏功能。
Circ Res. 2025 Apr 11;136(8):830-844. doi: 10.1161/CIRCRESAHA.124.325848. Epub 2025 Mar 17.
6
Modeling Cardiomyopathy and Arrhythmias in Induced Pluripotent Stem Cell-Derived Cardiomyocytes.诱导多能干细胞衍生心肌细胞中心肌病和心律失常的建模
Circ Genom Precis Med. 2018 Mar;11(3):e002088. doi: 10.1161/CIRCGEN.118.002088.
7
Genome Editing and Cardiac Arrhythmias.基因组编辑与心律失常。
Cells. 2023 May 11;12(10):1363. doi: 10.3390/cells12101363.
8
Memory T Cells Mediate Cardiac Allograft Vasculopathy and are Inactivated by Anti-OX40L Monoclonal Antibody.记忆 T 细胞介导心脏同种异体移植物血管病，并被抗 OX40L 单克隆抗体失活。
Cardiovasc Drugs Ther. 2014 Apr;28(2):115-22. doi: 10.1007/s10557-013-6502-9.
9
Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies.心肌疾病中心律失常的遗传基础和分子生物学。
Cardiovasc Res. 2020 Jul 15;116(9):1600-1619. doi: 10.1093/cvr/cvaa116.
10
(Filamin-C): A New(er) Player in the Field of Genetic Cardiomyopathies.（细丝蛋白-C）：遗传性心肌病领域的一个新（或更新）参与者。
Circ Cardiovasc Genet. 2017 Dec;10(6). doi: 10.1161/CIRCGENETICS.117.001959.
本文引用的文献
1
Overexpression of Wild-Type TMEM43 Improves Cardiac Function in Arrhythmogenic Right Ventricular Cardiomyopathy Type 5.野生型TMEM43的过表达改善5型致心律失常性右室心肌病的心脏功能。
Circ Res. 2025 Apr 11;136(8):830-844. doi: 10.1161/CIRCRESAHA.124.325848. Epub 2025 Mar 17.
2
A Drosophila melanogaster model for TMEM43-related arrhythmogenic right ventricular cardiomyopathy type 5.果蝇模型用于研究 TMEM43 相关的致心律失常性右室心肌病 5 型。
Cell Mol Life Sci. 2022 Jul 22;79(8):444. doi: 10.1007/s00018-022-04458-0.
3
Systems genetics analysis defines importance of TMEM43/ for cardiac- and metabolic-related pathways.系统遗传学分析定义了 TMEM43/在心脏和代谢相关通路中的重要性。
Physiol Genomics. 2022 Jan 1;54(1):22-35. doi: 10.1152/physiolgenomics.00066.2021. Epub 2021 Nov 12.
4
Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy.致心律失常性心肌病中 TMEM43 的异常积累伴随着跨壁基因表达的紊乱。
FASEB J. 2021 Nov;35(11):e21994. doi: 10.1096/fj.202100800R.
5
Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy.心肌细胞中 TMEM43 的单倍不足会激活 DNA 损伤反应途径，导致迟发性衰老相关的心肌成纤维细胞增生性心肌病。
Cardiovasc Res. 2021 Sep 28;117(11):2377-2394. doi: 10.1093/cvr/cvaa300.
6
Human pluripotent stem cell line (HDZi001-A) derived from a patient carrying the ARVC-5 associated mutation TMEM43-p.S358L.源自携带 ARVC-5 相关突变 TMEM43-p.S358L 患者的人多能干细胞系 (HDZi001-A)。
Stem Cell Res. 2020 Oct;48:101957. doi: 10.1016/j.scr.2020.101957. Epub 2020 Aug 19.
7
Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3β.糖原合酶激酶-3β抑制可改善致心律失常性右室心肌病 5 型所致严重心功能障碍和死亡。
Circulation. 2019 Oct;140(14):1188-1204. doi: 10.1161/CIRCULATIONAHA.119.040366. Epub 2019 Sep 5.
8
Arrhythmogenic Right Ventricular Cardiomyopathy-Associated Desmosomal Variants Are Rarely De Novo.致心律失常性右心室心肌病相关桥粒变异很少是新生的。
Circ Genom Precis Med. 2019 Aug;12(8):e002467. doi: 10.1161/CIRCGEN.119.002467. Epub 2019 Aug 6.
9
Luma is not essential for murine cardiac development and function.Luma 对于小鼠心脏的发育和功能并非必需。
Cardiovasc Res. 2018 Mar 1;114(3):378-388. doi: 10.1093/cvr/cvx205.
10
Long-Term Clinical Outcome of Arrhythmogenic Right Ventricular Cardiomyopathy in Individuals With a p.S358L Mutation in TMEM43 Following Implantable Cardioverter Defibrillator Therapy.植入式心律转复除颤器治疗后，携带TMEM43基因p.S358L突变的致心律失常性右室心肌病患者的长期临床结局
Circ Arrhythm Electrophysiol. 2016 Mar;9(3). doi: 10.1161/CIRCEP.115.003589.
Zotero 插件