• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

儿童尿中邻苯二甲酸酯代谢物与肺功能的关联：一项基于美国国家健康与营养检查调查（NHANES）的研究

Association of Urinary Phthalate Metabolites With Pulmonary Function in Children: A Study Based on the NHANES.

作者信息

Li Pei-Long, Fu Hong-Min, Li Feng, Liu Kai

机构信息

From the Kunming Children's Hospital & Children's Hospital Affiliated to Kunming Medical University, Kunming Medical University, Kunming, P.R. China (P.-l.L.); and Department of pulmonary and critical care medicine, Kunming Children's Hospital & Yunnan Key laboratory of Children's Major Disease Research, Kunming, P.R. China (P.-l.L., H.-m.F., F.L., K.L.).

出版信息

J Occup Environ Med. 2025 Jul 1;67(7):564-570. doi: 10.1097/JOM.0000000000003397. Epub 2025 Apr 10.

DOI:10.1097/JOM.0000000000003397
PMID:40209265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12237132/
Abstract

OBJECTIVE

The aim of the study was to evaluate the links between single and combined urinary phthalate metabolites and respiratory function in children.

METHODS

We analyzed the data from National Health and Nutrition Examination Survey (2007-2012) with the final analysis encompassed 1644 participants, those divided into four groups on average. This study investigated the correlation between ten prevalent phthalate metabolites in pediatric urine samples and four pulmonary function indices, employing multivariable linear regression, segmented linear regression, and the weighted quantile sum methodologies for analysis.

RESULTS

Significant negative correlations between eight phthalate metabolites. Additionally, the remaining seven phthalate metabolites showed significant negative associations with the predicted percentage of the ratio of forced expiratory volume in 1 second to forced vital capacity.

CONCLUSIONS

The combined effects of various phthalate metabolites are the primary contributors to the decline in lung function.

摘要

目的

本研究旨在评估儿童尿液中单一及复合邻苯二甲酸酯代谢物与呼吸功能之间的联系。

方法

我们分析了美国国家健康与营养检查调查（2007 - 2012年）的数据，最终分析纳入了1644名参与者，平均分为四组。本研究采用多变量线性回归、分段线性回归和加权分位数和方法，调查了儿童尿液样本中十种常见邻苯二甲酸酯代谢物与四种肺功能指标之间的相关性。

结果

八种邻苯二甲酸酯代谢物之间存在显著的负相关。此外，其余七种邻苯二甲酸酯代谢物与1秒用力呼气量与用力肺活量比值的预测百分比呈显著负相关。

结论

多种邻苯二甲酸酯代谢物的联合作用是肺功能下降的主要原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/152e92b4ea77/joem-67-0564-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/5fbfdc5620d3/joem-67-0564-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/9e8ff1561e83/joem-67-0564-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/659e78d9ca50/joem-67-0564-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/8b38268424ab/joem-67-0564-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/152e92b4ea77/joem-67-0564-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/5fbfdc5620d3/joem-67-0564-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/9e8ff1561e83/joem-67-0564-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/659e78d9ca50/joem-67-0564-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/8b38268424ab/joem-67-0564-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714d/12237132/152e92b4ea77/joem-67-0564-g005.jpg

相似文献

1
Association of Urinary Phthalate Metabolites With Pulmonary Function in Children: A Study Based on the NHANES.儿童尿中邻苯二甲酸酯代谢物与肺功能的关联：一项基于美国国家健康与营养检查调查（NHANES）的研究
J Occup Environ Med. 2025 Jul 1;67(7):564-570. doi: 10.1097/JOM.0000000000003397. Epub 2025 Apr 10.
2
The association of serum klotho with pulmonary function among US adults: a cross-sectional study.美国成年人血清klotho与肺功能的关联：一项横断面研究。
BMC Pulm Med. 2025 Jul 2;25(1):290. doi: 10.1186/s12890-025-03746-2.
3
Associations of urinary phthalate metabolites with Circadian Syndrome: evidence from NHANES.尿中邻苯二甲酸酯代谢物与昼夜节律综合征的关联：来自美国国家健康与营养检查调查（NHANES）的证据。
Front Public Health. 2025 Jun 27;13:1597489. doi: 10.3389/fpubh.2025.1597489. eCollection 2025.
4
Effects of exposure to phthalates and a phthalate substitute on food sensitization in children in China: evidence from a population study.接触邻苯二甲酸盐及其替代品对中国儿童食物致敏的影响：一项人群研究的证据
Environ Int. 2025 Jul;201:109597. doi: 10.1016/j.envint.2025.109597. Epub 2025 Jun 7.
5
Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis.常规胸部物理治疗与其他气道清除技术在囊性纤维化中的比较。
Cochrane Database Syst Rev. 2023 May 5;5(5):CD002011. doi: 10.1002/14651858.CD002011.pub3.
6
Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis.用于囊性纤维化患者肺部加重期的静脉用抗生素
Cochrane Database Syst Rev. 2025 Jan 20;1(1):CD009730. doi: 10.1002/14651858.CD009730.pub3.
7
Long-Term Exposure to Nitrogen Dioxide and Ozone and Respiratory Health in Children.儿童长期暴露于二氧化氮和臭氧与呼吸系统健康
Ann Am Thorac Soc. 2025 Feb;22(2):226-234. doi: 10.1513/AnnalsATS.202405-455OC.
8
Exposure to endocrine-disrupting plasticisers and lung function in children and adolescents: A systematic review and meta-analysis.接触内分泌干扰性塑化剂与儿童和青少年肺功能：系统评价和荟萃分析。
Environ Res. 2024 Feb 15;243:117751. doi: 10.1016/j.envres.2023.117751. Epub 2023 Dec 5.
9
General population-based lung function trajectories over the life course: an accelerated cohort study.基于一般人群的终生肺功能轨迹：一项加速队列研究。
Lancet Respir Med. 2025 Jul;13(7):611-622. doi: 10.1016/S2213-2600(25)00043-8. Epub 2025 May 15.
10
Association of PAEs with Precocious Puberty in Children: A Systematic Review and Meta-Analysis.邻苯二甲酸酯与儿童性早熟的关联：一项系统评价和Meta分析
Int J Environ Res Public Health. 2015 Dec 1;12(12):15254-68. doi: 10.3390/ijerph121214974.

本文引用的文献

1
Prenatal exposure to phthalates and childhood wheeze and asthma in the PROGRESS cohort.孕期邻苯二甲酸酯暴露与 PROGRESS 队列儿童喘息和哮喘。
Sci Total Environ. 2024 Dec 1;954:176311. doi: 10.1016/j.scitotenv.2024.176311. Epub 2024 Sep 16.
2
Association of phthalate exposure with pulmonary function in adults: NHANES 2007-2012.成人邻苯二甲酸盐暴露与肺功能的关联：2007 - 2012年美国国家健康与营养检查调查（NHANES）
Environ Res. 2023 Nov 15;237(Pt 2):116902. doi: 10.1016/j.envres.2023.116902. Epub 2023 Aug 23.
3
Longitudinal effects of prenatal exposure to plastic-derived chemicals and their metabolites on asthma and lung function from childhood into adulthood.
孕期暴露于源自塑料的化学物质及其代谢物对儿童期至成年期哮喘和肺功能的纵向影响。
Respirology. 2023 Mar;28(3):236-246. doi: 10.1111/resp.14386. Epub 2022 Oct 2.
4
Association between mixed exposure of phthalates and cognitive function among the U.S. elderly from NHANES 2011-2014: Three statistical models.美国老年人混合暴露于邻苯二甲酸酯与认知功能之间的关系：三种统计模型。 来自 NHANES 2011-2014 年的数据
Sci Total Environ. 2022 Jul 1;828:154362. doi: 10.1016/j.scitotenv.2022.154362. Epub 2022 Mar 6.
5
"Oxidative stress induced by phthalates in mammals: State of the art and potential biomarkers".邻苯二甲酸酯在哺乳动物中诱导的氧化应激：现状与潜在生物标志物
Environ Res. 2022 Apr 15;206:112636. doi: 10.1016/j.envres.2021.112636. Epub 2021 Dec 29.
6
Association between phthalate exposure and asthma risk: A meta-analysis of observational studies.邻苯二甲酸酯暴露与哮喘风险的关联：观察性研究的荟萃分析。
Int J Hyg Environ Health. 2020 Jul;228:113539. doi: 10.1016/j.ijheh.2020.113539. Epub 2020 Apr 24.
7
Repeated holdout validation for weighted quantile sum regression.加权分位数和回归的重复留出验证
MethodsX. 2019 Nov 22;6:2855-2860. doi: 10.1016/j.mex.2019.11.008. eCollection 2019.
8
Exposure to phthalates aggravates pulmonary function and airway inflammation in asthmatic children.接触邻苯二甲酸酯会加重哮喘儿童的肺功能和气道炎症。
PLoS One. 2018 Dec 17;13(12):e0208553. doi: 10.1371/journal.pone.0208553. eCollection 2018.
9
Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting.风险分析环境中高度相关数据的加权分位数和回归的特征描述
J Agric Biol Environ Stat. 2015 Mar;20(1):100-120. doi: 10.1007/s13253-014-0180-3. Epub 2014 Dec 24.
10
New insights into the mechanism of phthalate-induced developmental effects.邻苯二甲酸酯诱导发育效应的作用机制新认识。
Environ Pollut. 2018 Oct;241:674-683. doi: 10.1016/j.envpol.2018.05.095. Epub 2018 Jun 11.