儿童尿中邻苯二甲酸酯代谢物与肺功能的关联：一项基于美国国家健康与营养检查调查（NHANES）的研究
Association of Urinary Phthalate Metabolites With Pulmonary Function in Children: A Study Based on the NHANES.
作者信息
Li Pei-Long, Fu Hong-Min, Li Feng, Liu Kai
机构信息
From the Kunming Children's Hospital & Children's Hospital Affiliated to Kunming Medical University, Kunming Medical University, Kunming, P.R. China (P.-l.L.); and Department of pulmonary and critical care medicine, Kunming Children's Hospital & Yunnan Key laboratory of Children's Major Disease Research, Kunming, P.R. China (P.-l.L., H.-m.F., F.L., K.L.).
出版信息
J Occup Environ Med. 2025 Jul 1;67(7):564-570. doi: 10.1097/JOM.0000000000003397. Epub 2025 Apr 10.
OBJECTIVE
The aim of the study was to evaluate the links between single and combined urinary phthalate metabolites and respiratory function in children.
METHODS
We analyzed the data from National Health and Nutrition Examination Survey (2007-2012) with the final analysis encompassed 1644 participants, those divided into four groups on average. This study investigated the correlation between ten prevalent phthalate metabolites in pediatric urine samples and four pulmonary function indices, employing multivariable linear regression, segmented linear regression, and the weighted quantile sum methodologies for analysis.
RESULTS
Significant negative correlations between eight phthalate metabolites. Additionally, the remaining seven phthalate metabolites showed significant negative associations with the predicted percentage of the ratio of forced expiratory volume in 1 second to forced vital capacity.
CONCLUSIONS
The combined effects of various phthalate metabolites are the primary contributors to the decline in lung function.
目的
本研究旨在评估儿童尿液中单一及复合邻苯二甲酸酯代谢物与呼吸功能之间的联系。
方法
我们分析了美国国家健康与营养检查调查（2007 - 2012年）的数据，最终分析纳入了1644名参与者，平均分为四组。本研究采用多变量线性回归、分段线性回归和加权分位数和方法，调查了儿童尿液样本中十种常见邻苯二甲酸酯代谢物与四种肺功能指标之间的相关性。
结果
八种邻苯二甲酸酯代谢物之间存在显著的负相关。此外，其余七种邻苯二甲酸酯代谢物与1秒用力呼气量与用力肺活量比值的预测百分比呈显著负相关。
结论
多种邻苯二甲酸酯代谢物的联合作用是肺功能下降的主要原因。
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