Chaimoff C, Fishman P, Hart J, Djaldetti M
J Submicrosc Cytol. 1985 Jul;17(3):465-8.
Incubation of erythrocytes from controls and patients with colorectal carcinoma with tumor cells, or their metabolites, caused transformation of the normally-shaped cells to spherocytes. It is assumed that abnormal metabolites produced by malignant cells affect the cell membrane inducing the subsequent appearance of spherocytes. The increased destruction of these cells by the reticuloendothelial system may serve as an additional factor for the explanation of anemia accompanying malignant diseases.
将对照组和结直肠癌患者的红细胞与肿瘤细胞或其代谢产物一起孵育，会导致正常形状的细胞转变为球形红细胞。据推测，恶性细胞产生的异常代谢产物会影响细胞膜，从而导致球形红细胞随后出现。网状内皮系统对这些细胞的破坏增加，可能是解释恶性疾病伴发贫血的另一个因素。
