Shapiro E, Jeffs R D, Gearhart J P, Lepor H
J Urol. 1985 Aug;134(2):308-10. doi: 10.1016/s0022-5347(17)47139-4.
The surgical management of classical bladder exstrophy (functional bladder closure or urinary diversion) should be influenced by the inherent detrusor function of the exstrophied bladder. Cystometrograms performed previously on individuals with successful exstrophy closures demonstrate normal bladder function. The biochemical and neurophysiological properties of the exstrophied bladder have otherwise not been investigated. In this study radioligand receptor binding techniques were used to compare the density and equilibrium dissociation constant of muscarinic cholinergic receptors in control and exstrophy bladders. The density of muscarinic cholinergic receptors in the control and exstrophy groups was 1.97 plus or minus 0.29 and 1.44 plus or minus 0.21 fmol. per microgram deoxyribonucleic acid (mean plus or minus standard error of mean), respectively. The dissociation constant of the control and exstrophy groups was 0.15 plus or minus 0.02 and 0.14 plus or minus 0.02 nM. (mean plus or minus standard error of mean), respectively. These data show that the muscarinic receptor density and binding affinity in control and exstrophy bladders are similar. Therefore, the neurophysiological composition of the exstrophied bladder is not grossly altered during the anomalous development.
经典膀胱外翻的手术治疗（功能性膀胱闭合或尿流改道）应受外翻膀胱固有逼尿肌功能的影响。先前对膀胱外翻闭合成功个体进行的膀胱测压显示膀胱功能正常。然而，外翻膀胱的生化和神经生理特性尚未得到研究。在本研究中，使用放射性配体受体结合技术比较对照膀胱和外翻膀胱中毒蕈碱胆碱能受体的密度和平衡解离常数。对照组和外翻组中毒蕈碱胆碱能受体的密度分别为每微克脱氧核糖核酸1.97±0.29和1.44±0.21飞摩尔（平均值±平均标准误差）。对照组和外翻组的解离常数分别为0.15±0.02和0.14±0.02纳摩尔（平均值±平均标准误差）。这些数据表明，对照膀胱和外翻膀胱中的毒蕈碱受体密度和结合亲和力相似。因此，外翻膀胱的神经生理组成在异常发育过程中未发生明显改变。
