Afarinesh Mohammad Reza, Ahmadi Bi Bi Marzieh, Sabzalizadeh Mansoureh, Golshan Faly, Sheibani Vahid
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; Cognitive Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Physiol Behav. 2025 Jun 1;295:114911. doi: 10.1016/j.physbeh.2025.114911. Epub 2025 Apr 8.
Understanding the enhancement of neuronal performance through the interaction of various sensory stimuli and evaluating how these interactions influence neuronal responses and sensorimotor behaviors is critical. This study investigates the simultaneous effects of tactile stimulation (TS) and sensory deprivation of whiskers on the receptive field properties of barrel cortex neurons in Wistar rats. Male rats were subjected to whisker deprivation (WD) or TS for 21 days from birth. Neuronal responses to controlled deflections of principal and adjacent whiskers were assessed using single-unit recordings from the barrel cortex. Results indicated that while WD reduced the excitatory receptive fields of neurons, the magnitude of ON and OFF responses returned to control group levels following TS, suggesting improved neuronal function. These findings demonstrate that tactile stimulation can compensate for deficits caused by sensory deprivation.
了解通过各种感觉刺激的相互作用来增强神经元性能，并评估这些相互作用如何影响神经元反应和感觉运动行为至关重要。本研究调查了触觉刺激（TS）和胡须感觉剥夺对Wistar大鼠桶状皮层神经元感受野特性的同时影响。雄性大鼠从出生起接受21天的胡须剥夺（WD）或TS处理。使用来自桶状皮层的单单位记录评估神经元对主要和相邻胡须受控偏转的反应。结果表明，虽然WD减少了神经元的兴奋性感受野，但TS后ON和OFF反应的幅度恢复到对照组水平，表明神经元功能得到改善。这些发现表明，触觉刺激可以弥补感觉剥夺造成的缺陷。
