Josephson S, Ericson A C, Sjöquist M
J Urol. 1985 Aug;134(2):391-5. doi: 10.1016/s0022-5347(17)47184-9.
Partial obstruction of one ureter was created in newborn rats and its effects were studied after the rats matured. The obstructed pelvis was found to be considerably enlarged. The parenchymal weight was 19 per cent lower and the whole kidney glomerular filtration rate was 43 per cent lower than on the contralateral intact side (p less than 0.001); however, these figures probably include a compensatory increase on the intact side. In the central part of the cortex, the glomerular filtration rate/mg. cortex was 21 per cent lower in the hydronephrotic kidney (p less than 0.02), but there was no intracortical redistribution. The glomerular density in this region was 24 per cent higher on the hydronephrotic side (p less than 0.001), because the glomeruli were crammed together in the distended cortex. No redistribution of glomeruli was found. The results are discussed and compared with previous findings from our laboratory. In this model, partially obstructive uropathy was found to cause only a moderate depression, but no redistribution, of the filtration.
在新生大鼠中造成一侧输尿管部分梗阻，并在大鼠成熟后研究其影响。发现梗阻侧肾盂明显增大。实质重量比健侧低19%，全肾肾小球滤过率比健侧完整的一侧低43%（p<0.001）；然而，这些数值可能包括了健侧的代偿性增加。在皮质中央部分，肾积水肾脏的肾小球滤过率/毫克皮质比健侧低21%（p<0.02），但没有皮质内再分布。该区域肾积水侧的肾小球密度比健侧高24%（p<0.001），因为肾小球在扩张的皮质中挤在一起。未发现肾小球再分布。对结果进行了讨论并与我们实验室之前的发现进行了比较。在这个模型中，发现部分梗阻性尿路病仅导致滤过有中度降低，但没有再分布。
