Josephson S
J Urol. 1985 Jun;133(6):1099-103. doi: 10.1016/s0022-5347(17)49389-x.
Partial obstruction of 1 ureter was created in newborn rats and its effects were studied in the adult rat. The obstructed renal pelvis was found to be about 6 times enlarged and the weight of the kidney was 85 per cent of the contralateral intact one. Despite considerable distortion of the inner medulla on the obstructed side, no loss of weight in this region was observed. The only changes observed with respect to tissue concentrations--which were significantly due to the obstruction--were increases in urea in the cortex (110 per cent) and in potassium in the inner medulla (21 per cent); thus, the changes were few and, in part, moderate. The findings are compared with previous observations of solute excretions and the pathophysiological implications are discussed. The conclusion is that although the inner medulla was considerably distorted, the solute content was far from being affected to a corresponding degree--at least not in this experimental preparation.
在新生大鼠中造成一侧输尿管部分梗阻，并在成年大鼠中研究其影响。发现梗阻侧肾盂增大约6倍，肾脏重量为对侧完整肾脏的85%。尽管梗阻侧内髓质有相当程度的变形，但该区域未观察到重量减轻。观察到的与组织浓度相关的唯一变化（这些变化明显是由梗阻引起的）是皮质中尿素增加（110%）和内髓质中钾增加（21%）；因此，变化较少，且部分变化程度适中。将这些发现与先前关于溶质排泄的观察结果进行比较，并讨论其病理生理学意义。结论是，尽管内髓质有相当程度的变形，但溶质含量远未受到相应程度的影响——至少在本实验制剂中是这样。
