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肿瘤浸润淋巴细胞免疫疗法走向成熟:美国国立癌症研究所外科分支的发展历程

Tumor-infiltrating lymphocyte immunotherapy comes of age: a journey of development in the Surgery Branch, NCI.

作者信息

Goff Stephanie L, Rosenberg Steven A

机构信息

Surgery Branch, National Cancer Institute Center for Cancer Research, Bethesda, Maryland, USA

Surgery Branch, National Cancer Institute Center for Cancer Research, Bethesda, Maryland, USA.

出版信息

J Immunother Cancer. 2025 Apr 9;13(4):e011734. doi: 10.1136/jitc-2025-011734.

DOI:10.1136/jitc-2025-011734
PMID:40210239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11987153/
Abstract

The early development of tumor-infiltrating lymphocytes into an effective clinical strategy was fundamentally the work of hundreds of scientists and clinicians within the Surgery Branch of the National Cancer Institute under the leadership of Steven Rosenberg. That journey brought new insights into the tumor-immune cell interface and ultimately helped create a new first-in-class therapeutic for patients with metastatic cancer.

摘要

肿瘤浸润淋巴细胞早期发展成为一种有效的临床策略,从根本上来说是在史蒂文·罗森伯格的领导下,美国国立癌症研究所外科分部数百名科学家和临床医生的工作成果。这一历程为肿瘤与免疫细胞的界面带来了新的见解,并最终帮助为转移性癌症患者开发出了一种全新的一流疗法。

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本文引用的文献

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Neoantigen-specific tumor-infiltrating lymphocytes in gastrointestinal cancers: a phase 2 trial.胃肠道癌中针对新抗原的肿瘤浸润淋巴细胞:一项2期试验。
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Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma.转移性黑色素瘤患者肿瘤浸润淋巴细胞过继性转移前淋巴细胞清除强度的随机前瞻性评估
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