Naganuma M
Jpn Circ J. 1985 May;49(5):545-52. doi: 10.1253/jcj.49.545.
The clinical manifestations, infective microorganisms, underlying diseases, complications and prognosis of infective endocarditis (IE) were studied in 17 current patients. Data were compared with 101 previous cases reported in Japan. Most patients with IE (110/118 = 93.2%) had underlying heart diseases. IE was noted most often in patients with ventricular septal defect (VSD) and tetralogy of Fallot. The incidence of post operative endocarditis was high (29.4% in the present series and 9.0% in the overall series), too. Streptococcus viridans, Staphylococcus aureus and GNB were the most common etiologic agents with incidences of 28.8% (34/118), 25.4% (30/118) and 9.3% (11/118), respectively. Almost half of the deaths from IE were caused by s. aureus. The mortality was 11.9% (14/118) in both series. The death rate from candida albicans was 100%, from s. aureus 33.3% (10/30) and from str. viridans 5.9% (2/34) in both series. Culture negative patients accounted for 11.9% (14/118) in both series. Complications which did not involve the valves were noted in one patient with cerebral emboli and in two patients with pulmonary infarction in the present series. Cerebral emboli phenomena were seen 8 cases of the overall series, 4 of whom died.
对17例现患感染性心内膜炎（IE）患者的临床表现、感染微生物、基础疾病、并发症及预后进行了研究。将数据与日本此前报道的101例病例进行了比较。大多数IE患者（110/118 = 93.2%）有基础心脏病。IE最常发生于室间隔缺损（VSD）和法洛四联症患者。术后心内膜炎的发生率也很高（本系列为29.4%，总体系列为9.0%）。草绿色链球菌、金黄色葡萄球菌和革兰阴性菌（GNB）是最常见的病原体，发生率分别为28.8%（34/118）、25.4%（30/118）和9.3%（11/118）。几乎一半的IE死亡病例由金黄色葡萄球菌引起。两个系列的死亡率均为11.9%（14/118）。两个系列中白色念珠菌的死亡率为100%，金黄色葡萄球菌为33.3%（10/30），草绿色链球菌为5.9%（2/34）。两个系列中血培养阴性患者占11.9%（14/118）。本系列中1例发生脑栓塞和2例发生肺梗死的患者出现了不涉及瓣膜的并发症。总体系列中有8例出现脑栓塞现象，其中4例死亡。
