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成像皮肤的图像质量评估,一种用于术中肿瘤成像的新型可拉伸X射线探测器。

Image quality evaluation of imaging skins, a novel stretchable X-ray detector for intraoperative tumour imaging.

作者信息

Dietsch Solène, Allan Harry, Lindenroth Lukas, Moss Robert, Stilli Agostino, Stoyanov Danail

机构信息

Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, W1W 7EJ, UK.

Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.

出版信息

Sci Rep. 2025 Apr 11;15(1):12371. doi: 10.1038/s41598-025-96768-z.

DOI:10.1038/s41598-025-96768-z
PMID:40211008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11985977/
Abstract

This paper presents the development of a novel X-ray detector composed of silicone elastomer and GOS:Tb, which we refer to as imaging skins. These detectors were integrated into a custom X-ray system to convert radiation into visible light. Our study focused on how fabrication parameters such as thickness and concentration impact sensor linearity, considering their potential application directly on the skin or organs to identify tumour margins during surgery. In addition, we examined how the stretching capabilities of these detectors influenced the image quality. Our imaging detection stack demonstrated consistent linearity across various fabrication parameters with the coefficient of determination ([Formula: see text]) more than 0.99998, showing that the silicone elastomer does not affect the conversion of the X-ray into light. We achieved a spatial resolution of 1.16-1.42 lp/mm at 10% of the Spatial Frequency Response using a 0.5-mm thick sensor. This study represents a first step towards integrating stretchable X-ray detectors into clinical settings, particularly on curved surfaces, to unlock their full potential in complex surgical configurations. It also highlights the need for a deeper understanding of the interactions between X-rays and detector materials to fully interpret the observed effects.

摘要

本文介绍了一种由硅橡胶和GOS:Tb组成的新型X射线探测器的研发情况,我们将其称为成像皮肤。这些探测器被集成到一个定制的X射线系统中,用于将辐射转化为可见光。我们的研究重点在于诸如厚度和浓度等制造参数如何影响传感器的线性度,同时考虑到它们在手术期间直接应用于皮肤或器官以识别肿瘤边缘的潜在用途。此外,我们还研究了这些探测器的拉伸能力如何影响图像质量。我们的成像检测堆栈在各种制造参数下均表现出一致的线性度,决定系数([公式:见原文])大于0.99998,表明硅橡胶不会影响X射线向光的转换。使用0.5毫米厚的传感器,在空间频率响应的10%时,我们实现了1.16 - 1.42 lp/mm的空间分辨率。这项研究代表了将可拉伸X射线探测器集成到临床环境,特别是在曲面上,以释放其在复杂手术配置中的全部潜力的第一步。它还强调了需要更深入地了解X射线与探测器材料之间的相互作用,以便充分解释观察到的效果。

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本文引用的文献

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CT and X-ray contrast agents: Current clinical challenges and the future of contrast.CT 和 X 射线造影剂:当前临床面临的挑战和造影的未来。
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Interactions of Inhaled Liposome with Macrophages and Neutrophils Determine Particle Biofate and Anti-Inflammatory Effect in Acute Lung Inflammation.吸入脂质体与巨噬细胞和中性粒细胞的相互作用决定了急性肺部炎症中颗粒的生物命运和抗炎效果。
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