血脂水平在不吃早餐与高尿酸血症关系中的作用：一个有调节的中介模型。
The role of lipid profile in the relationship between skipping breakfast and hyperuricemia: a moderated mediation model.
作者信息
Deng Zhihao, Zhou Feixiang, Tian Gang, Wang Qi, Yan Yan
机构信息
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, 410078, Hunan, China.
Henan Province Hypertension Precision Prevention and Control Engineering Research Center, Henan Provincial People's Hospital, 7 Weiwu Road, Zhengzhou, Henan, China.
出版信息
BMC Public Health. 2025 Apr 10;25(1):1347. doi: 10.1186/s12889-025-22594-7.
BACKGROUND
The prevalence of hyperuricemia is rising among oilfield workers in China. This study aimed to explore the underlying mechanisms between skipping breakfast and serum uric acid.
METHODS
A total of 21,676 participants aged 20--60 from a large oilfield company in China were included. Association analysis, multivariate logistic, subgroup analysis, and moderated mediation analysis were performed to assess the association between skipping breakfast and hyperuricemia.
RESULTS
We found that 24.48% of oilfield employees had hyperuricemia. The odds ratio of hyperuricemia linked to skipping breakfast was 0.78 (95%CI: 0.69--0.88). The association between skipping breakfast and hyperuricemia was mediated by TC (22.32%) and LDL-C (21.57%). Age moderated this mediation, with significant effects for skipping breakfast (ß: 0.553, 95%CI: 0.042--1.063) and TC (ß: -0.339, 95%CI: -0.586- -0.093). Similar results were observed for LDL-C mediation (ß: 0.522, 95%CI: 0.009--1.035; ß: -0.585, 95%CI: -0.894- -0.276).
CONCLUSION
Skipping breakfast positively influenced hyperuricemia through TC and LDL-C. Age moderated the relationship between skipping breakfast and serum uric acid. Greater attention should be given to young employees in Chinese oilfield enterprises, with dietary interventions implemented to reduce abnormal lipids metabolism and hyperuricemia.
背景
中国油田工人高尿酸血症的患病率正在上升。本研究旨在探讨不吃早餐与血清尿酸之间的潜在机制。
方法
纳入了来自中国一家大型油田公司的21676名年龄在20至60岁之间的参与者。进行了关联分析、多因素逻辑回归分析、亚组分析和调节中介分析，以评估不吃早餐与高尿酸血症之间的关联。
结果
我们发现24.48%的油田员工患有高尿酸血症。不吃早餐与高尿酸血症相关的比值比为0.78（95%置信区间：0.69 - 0.88）。不吃早餐与高尿酸血症之间的关联由总胆固醇（TC，22.32%）和低密度脂蛋白胆固醇（LDL-C，21.57%）介导。年龄调节了这种中介作用，不吃早餐（β：0.553，95%置信区间：0.042 - 1.063）和总胆固醇（β：-0.339，95%置信区间：-0.586 - -0.093）有显著影响。低密度脂蛋白胆固醇介导的情况也观察到类似结果（β：0.522，95%置信区间：0.009 - 1.035；β：-0.585，95%置信区间：-0.894 - -0.276）。
结论
不吃早餐通过总胆固醇和低密度脂蛋白胆固醇对高尿酸血症有正向影响。年龄调节了不吃早餐与血清尿酸之间的关系。中国油田企业应更加关注年轻员工，实施饮食干预以减少脂质代谢异常和高尿酸血症。
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