School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
BMC Public Health. 2024 Oct 30;24(1):3007. doi: 10.1186/s12889-024-20457-1.
Numerous studies have indicated a growing prevalence of hyperuricemia. Elevated levels of serum uric acid (SUA) have been established as influential factors in conditions such as obesity, metabolic syndrome, diabetes mellitus, gout, and cardiovascular disease. Overweight and obesity are closely related to an increase in SUA. Our objective is to demonstrate the mediating role of liver enzyme in the correlation between body mass index (BMI) and SUA.
A total of 5925 adults aged 18 to 65 were included in this cross-sectional study. Logistic regression and mediation analysis were used to investigate the relationship between BMI and hyperuricemia as well as liver enzyme levels. Standard methods were used to determine the biochemical indexes, including SUA, liver enzymes, and blood lipids in the collected samples.
The study revealed that the prevalence of hyperuricemia was 28.0%. Furthermore, the prevalence of overweight and obesity was as high as 48.5%, with 70.7% of this subgroup presenting with hyperuricemia. There was a positive correlation between BMI and hyperuricemia, and elevated levels of liver enzymes (ALT, AST, GGT) were associated with a higher risk of hyperuricemia. The study also observed a positive correlation between BMI and liver enzymes (ALT, AST, GGT). The study findings suggested that ALT, AST, and GGT played significant mediating roles in the relationship between BMI and SUA. Specifically, the unadjusted model revealed that ALT and GGT accounted for 22.12% and 18.13% of the mediation effects, respectively.
The study found that BMI is associated with hyperuricemia, where liver enzyme abnormalities may have a mediating role. It is suggested that being overweight or obese may affect liver enzyme levels, leading to increased SUA levels. Controlling weight and liver enzyme levels may help prevent and treat hyperuricemia.
大量研究表明，高尿酸血症的患病率不断上升。血清尿酸（SUA）水平升高已被确定为肥胖、代谢综合征、糖尿病、痛风和心血管疾病等疾病的影响因素。超重和肥胖与 SUA 升高密切相关。我们的目的是证明肝酶在体重指数（BMI）与 SUA 之间的相关性中起中介作用。
本横断面研究共纳入 5925 名 18 至 65 岁的成年人。采用 logistic 回归和中介分析来研究 BMI 与高尿酸血症以及肝酶水平之间的关系。采用标准方法测定所采集样本的生化指标，包括 SUA、肝酶和血脂。
研究显示，高尿酸血症的患病率为 28.0%。此外，超重和肥胖的患病率高达 48.5%，其中 70.7%的亚组存在高尿酸血症。BMI 与高尿酸血症呈正相关，肝酶（ALT、AST、GGT）升高与高尿酸血症风险增加相关。研究还观察到 BMI 与肝酶（ALT、AST、GGT）呈正相关。研究结果表明，ALT、AST 和 GGT 在 BMI 与 SUA 之间的关系中起显著的中介作用。具体来说，未调整模型显示，ALT 和 GGT 分别占中介效应的 22.12%和 18.13%。
本研究发现 BMI 与高尿酸血症相关，肝酶异常可能起中介作用。超重或肥胖可能会影响肝酶水平，导致 SUA 水平升高。控制体重和肝酶水平可能有助于预防和治疗高尿酸血症。
