Yamada S, Takezawa J, Nagamine T, Ichikawa K, Arai T, Kobayashi S
Jpn J Med. 1985 May;24(2):109-20. doi: 10.2169/internalmedicine1962.24.109.
Morphological changes of interlobular bile ducts in asymptomatic or symptomatic primary biliary cirrhosis (PBC) and chronic hepatitis with ductal lesions were investigated. It was supposed that bile duct lesions found in PBC and chronic hepatitis could be distinguished histologically. There were identical epithelial changes between symptomatic PBC and asymptomatic one, but granulomas were more often found in asymptomatic PBC than in symptomatic PBC. Numbers of interlobular bile ducts per portal tract and the rates of portal tracts without interlobular duct in asymptomatic PBC were intermediate between symptomatic PBC and chronic hepatitis. Serial sections revealed that some bile ducts were able to be followed by ductules in asymptomatic PBC. From these results, numbers of interlobular bile ducts are undoubtedly decreased in asymptomatic PBC but not so much as in symptomatic one. This observation may be attributable partially for taking asymptomatic course.
对无症状或有症状的原发性胆汁性肝硬化（PBC）以及伴有胆管病变的慢性肝炎小叶间胆管的形态学变化进行了研究。据推测，PBC和慢性肝炎中发现的胆管病变在组织学上可以区分。有症状的PBC和无症状的PBC之间存在相同的上皮变化，但无症状PBC中比有症状PBC中更常发现肉芽肿。无症状PBC中每个门管区小叶间胆管的数量以及无小叶间胆管的门管区比例介于有症状PBC和慢性肝炎之间。连续切片显示，在无症状PBC中一些胆管能够延续为小胆管。从这些结果来看，无症状PBC中小叶间胆管数量无疑减少，但不像有症状PBC中减少得那么多。这一观察结果可能部分归因于其无症状病程。
