Teranishi Y, Iriuchijima J
Jpn J Physiol. 1985;35(1):139-46. doi: 10.2170/jjphysiol.35.139.
Blood flow in the terminal aorta or superior mesenteric artery was recorded in conscious one-clip, two-kidney renovascular hypertensive rats and normal control rats with a chronically implanted electromagnetic flow probe. An indwelling catheter for direct measurement of arterial pressure was inserted into the terminal aorta in rats with a flow probe around the superior mesenteric artery. In the hindquarter area supplied by the terminal aorta, the elevation of vascular resistance in hypertensive rats in relation to normal rats was close to the average over the whole body. However, it was about 40% more intense than the average in the superior mesenteric area. Quantitatively, the hindquarter and superior mesenteric beds in hypertensive rats contributed about a quarter and a third of the decrease in total vascular conductance, respectively. Plots of superior mesenteric flow per body weight against arterial pressure at rest for 51 measurements in 9 hypertensive rats revealed an inverse relation between these two variables. These findings indicate that elevation of vascular resistance in the superior mesenteric area and probably the splanchnic area in general play an important role in one-clip, two-kidney renovascular hypertension.
用长期植入的电磁流量探头记录清醒的单夹双肾肾血管性高血压大鼠和正常对照大鼠的终末主动脉或肠系膜上动脉的血流。在肠系膜上动脉周围放置流量探头的大鼠中，将一根用于直接测量动脉压的留置导管插入终末主动脉。在终末主动脉供应的后肢区域，高血压大鼠相对于正常大鼠的血管阻力升高接近全身的平均值。然而，它比肠系膜上区域的平均值高约40%。从数量上看，高血压大鼠的后肢和肠系膜上血管床分别导致总血管传导率下降的约四分之一和三分之一。对9只高血压大鼠的51次测量结果进行的静息状态下每体重肠系膜上血流量与动脉压的绘图显示，这两个变量之间呈负相关。这些发现表明，肠系膜上区域以及可能一般内脏区域的血管阻力升高在单夹双肾肾血管性高血压中起重要作用。
