Teranishi Y, Shimamoto H, Iriuchijima J
Department of Physiology, Hiroshima University School of Medicine, Japan.
Jpn J Physiol. 1988;38(6):777-85. doi: 10.2170/jjphysiol.38.777.
Mean arterial pressure and three regional blood flows--renal, superior mesenteric, and hindquarter flows--were monitored in conscious normotensive control rats (NCR), in two-kidney, one-clip (two-kidney), and in one-kidney, one-clip (one-kidney) hypertensive rats. After administering captopril, an angiotensin-converting enzyme inhibitor, mean arterial pressure decreased in all three groups. However, lowering of arterial pressure was not statistically significant in any of the groups. Renal flow increased significantly in the intact artery of two-kidney hypertensive rats, whereas it did not significantly increase in the clipped artery of one-kidney hypertensive rats and in the intact artery of NCR. Superior mesenteric flow increased significantly only in one-kidney hypertensive rats. Hindquarter flow did not significantly change in the three groups. Regional resistance reduced significantly in not only renal but also in superior mesenteric vascular area in two-kidney hypertensive rats, whereas it did not reduce significantly in these two vascular areas in one-kidney hypertensive rats and in NCR. The present findings show that the renin-angiotensin-mediated vasoconstriction plays a role in not only renal but also in superior mesenteric vascular area in two-kidney hypertensive rats, whereas it hardly plays a role in these three vascular beds in one-kidney hypertensive rats.
在清醒的正常血压对照大鼠（NCR）、两肾一夹（双肾）和一肾一夹（单肾）高血压大鼠中监测平均动脉压和三个区域的血流——肾血流、肠系膜上动脉血流和后肢血流。给予血管紧张素转换酶抑制剂卡托普利后，三组大鼠的平均动脉压均下降。然而，动脉压的降低在任何一组中均无统计学意义。双肾高血压大鼠完整动脉的肾血流显著增加，而单肾高血压大鼠夹闭动脉的肾血流和NCR完整动脉的肾血流均未显著增加。仅在单肾高血压大鼠中肠系膜上动脉血流显著增加。三组大鼠的后肢血流均无显著变化。双肾高血压大鼠不仅肾血管区域阻力显著降低，肠系膜上血管区域阻力也显著降低，而单肾高血压大鼠和NCR在这两个血管区域的阻力均未显著降低。目前的研究结果表明，肾素 - 血管紧张素介导的血管收缩在双肾高血压大鼠的肾血管和肠系膜上血管区域均起作用，而在单肾高血压大鼠的这三个血管床中几乎不起作用。
