Lengvenyte Aiste, Olié Emilie, Cognasse Fabrice, Hamzeh-Cognassse Hind, Alacreu-Crespo Adrian, Courtet Philippe
Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France.
Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
Brain Behav Immun Health. 2025 Mar 24;45:100984. doi: 10.1016/j.bbih.2025.100984. eCollection 2025 May.
Interpersonal stress is a major precipitant of suicidal ideation (SI) and suicide attempts (SA), yet the underlying biological mechanisms remain unclear. This study examined dynamic plasma concentrations of inflammatory, platelet activation, and neurotrophic markers during acute social stress in 76 depressed women (mean age: 39.7 ± 1.39 years) with and without SA history or recent SI. Participants underwent the Trier Social Stress Test, with biomarkers measured at five time points before, during, and after the stressor. Covariate-adjusted growth curve models and area under the curve analyses were applied. SI was associated with elevated overall TNF-α levels (0.82 ± 0.05 vs. 0.61 ± 0.05, p = 0.039). Participants without SI showed cubic trajectories in TNF-α (t = 4.76, p < 0.001) and MIP-1β (t = 2.12, p = 0.035), and quadratic trajectories in platelet markers TSP-1 (t = -2.42, p = 0.016), PF-4 (t = -2.25, p = 0.025), and NAP-2 (t = -2.43, p = 0.016), which were absent in participants with SI. Cubic patters in inflammatory responses were also observed in participants without SA history, but not in suicide attempters (TNF-α: t = 3.15, p = 0.030; MIP-1β: t = 2.74, p = 0.007). Meanwhile, participants with SI or SA, but not those without, showed a linear BDNF increase (t = 2.39, p = 0.017; t = 2.28, p = 0.024, respectively). These findings suggest that SI and SA may be associated with impaired dynamic immune-inflammatory, platelet, and neurotrophic systems responses to acute interpersonal stress, reflecting systemic biological rigidity.
人际压力是自杀意念（SI）和自杀未遂（SA）的主要诱因，但其潜在的生物学机制仍不清楚。本研究检测了76名有或无SA病史或近期SI的抑郁症女性（平均年龄：39.7±1.39岁）在急性社会压力期间炎症、血小板活化和神经营养标志物的动态血浆浓度。参与者接受了特里尔社会压力测试，在压力源之前、期间和之后的五个时间点测量生物标志物。应用协变量调整生长曲线模型和曲线下面积分析。SI与总体TNF-α水平升高相关（0.82±0.05对0.61±0.05，p = 0.039）。无SI的参与者在TNF-α（t = 4.76，p < 0.001）和MIP-1β（t = 2.12，p = 0.035）中表现出三次轨迹，在血小板标志物TSP-1（t = -2.42，p = 0.016）、PF-4（t = -2.25，p = 0.025）和NAP-2（t = -2.43，p = 0.016）中表现出二次轨迹，而有SI的参与者则没有。在无SA病史的参与者中也观察到炎症反应的三次模式，但自杀未遂者中未观察到（TNF-α：t = 3.15，p = 0.030；MIP-1β：t = 2.74，p = 0.007）。同时，有SI或SA的参与者，而非无SI或SA的参与者，显示BDNF呈线性增加（分别为t = 2.39，p = 0.017；t = 2.28，p = 0.024）。这些发现表明，SI和SA可能与对急性人际压力的动态免疫炎症、血小板和神经营养系统反应受损有关，反映了全身生物学僵化。
