Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France; IGF, University of Montpellier, CNRS, INSERM, Montpellier, France; Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius University, Vilnius, Lithuania.
Université Jean Monnet, Mines Saint-Étienne, INSERM, U 1059 Sainbiose, Saint-Étienne, France; Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France.
Psychoneuroendocrinology. 2024 Oct;168:107119. doi: 10.1016/j.psyneuen.2024.107119. Epub 2024 Jul 6.
Identifying circulating biomarkers associated with prospective suicidal ideation (SI) and depression could help better understand the dynamics of these phenomena and identify people in need of intense care. In this study, we investigated the associations between baseline peripheral biomarkers implicated in neuroplasticity, vascular homeostasis and inflammation, and prospective SI and depression severity during 6 months of follow-up in patients with mood disorders.
149 patients underwent a psychiatric evaluation and gave blood to measure 32 plasma soluble proteins. At follow-up, SI incidence over six months was measured with the Columbia Suicide Severity Rating Scale, and depressive symptoms were assessed with the Inventory for Depressive Symptomatology. Ninety-six patients provided repeated blood samples. Statistical analyses included Spearman partial correlation and Elastic Net regression, followed by the covariate-adjusted regression models.
51.4 % (N = 71) of patients reported SI during follow-up. After adjustment for covariates, higher baseline levels of interferon-γ were associated with SI occurrence during follow-up. Higher baseline interferon-γ and lower orexin-A were associated with increased depression severity, and atypical and anxious, but not melancholic, symptoms. There was also a tendency for associations of elevated baseline levels of interferon-γ, interleukin-1β, and lower plasma serotonin levels with SI at the six-month follow-up time point. Meanwhile, reduction in transforming growth factor- β1 (TGF-β1) plasma concentration correlated with atypical symptoms reduction.
We identified interferon-γ and orexin-A as potential predictive biomarkers of SI and depression, whereas TGF-β1 was identified as a possible target of atypical symptoms.
识别与前瞻性自杀意念（SI）和抑郁相关的循环生物标志物，有助于更好地了解这些现象的动态，并识别需要加强护理的人群。在这项研究中，我们研究了基线时与神经可塑性、血管稳态和炎症相关的外周生物标志物与心境障碍患者 6 个月随访期间前瞻性 SI 和抑郁严重程度之间的关联。
149 名患者接受了精神病学评估，并采集血液以测量 32 种血浆可溶性蛋白。在随访时，用哥伦比亚自杀严重程度评定量表（Columbia Suicide Severity Rating Scale）测量 6 个月内 SI 的发生率，用抑郁症状评定量表（Inventory for Depressive Symptomatology）评估抑郁症状。96 名患者提供了重复的血液样本。统计分析包括 Spearman 偏相关和弹性网回归，然后是协变量调整的回归模型。
51.4%（N=71）的患者在随访期间报告了 SI。在调整了协变量后，较高的基线干扰素-γ水平与随访期间的 SI 发生有关。较高的基线干扰素-γ和较低的食欲素-A 与抑郁严重程度增加有关，与非典型和焦虑有关，但与忧郁无关。干扰素-γ、白细胞介素-1β和较低的血浆 5-羟色胺水平的基线水平升高也与 6 个月随访时的 SI 有关。与此同时，转化生长因子-β1（TGF-β1）血浆浓度的降低与非典型症状的减轻有关。
我们发现干扰素-γ和食欲素-A 是 SI 和抑郁的潜在预测生物标志物，而 TGF-β1 可能是非典型症状的靶点。
