Bhat Mansoor Ahmad, Radu Tanja, Martín-Fabiani Ignacio, Kolokathis Panagiotis D, Papadiamantis Anastasios G, Wagner Stephan, Kohl Yvonne, Witters Hilda, Gebbink Wouter A, Rodriguez Yentl Pareja, Cardelini Giuseppe, Degens Roel, Burzic Ivana, Serrano Beatriz Alfaro, Pretschuh Claudia, Santamaría-Aranda Eduardo, Contreras-García Elena, Sinic Judith, Jocham Christoph, Cohen Dror, Maor Ze'evi, Assis Assaf, Panák Ondrej, Novak Uroš, Hans Sukriti, Biesemeier Antje, Camilleri Pau, Sánchez Fruela Pérez, Arblaster Thomas, Thonemann Nils, Guinée Jeroen, Pipino Andrea, Çelen Onur, Alwe Hariprasad, Drexel Roland, Welz Roland, Meier Florian, Oliva Indre Piragyte-Langa, Tagorti Ghada, Hardy Barry, Velimirovic Milica
School of Architecture, Building and Civil Engineering, Loughborough University, Loughborough, Leicestershire LE11 3TU, United Kingdom.
Department of Materials, Loughborough University, Loughborough LE11 3TU, United Kingdom.
Comput Struct Biotechnol J. 2025 Mar 17;29:60-71. doi: 10.1016/j.csbj.2025.03.022. eCollection 2025.
The strategic objective of the Safe and sustainable by design of next generation chemicals and materials (SSbD4CheM) project is to develop screening and testing strategies for a variety of substances and materials to ensure safer and more sustainable products in line with the Sustainable Products Initiative. SSbD4CHeM is focusing on chemical safety using new approach methods, including studies without animal models and tools. Additionally, it integrates environmental sustainability for the implementation of the Safe and Sustainable by Design (SSbD) framework including risk assessment and life cycle assessment. New methods and models for safety and sustainability assessment along chemical, material and product life cycles will be developed, validated, and applied to three case studies, including biobased self-cleaning, water repellent, and antimicrobial treatments for textiles, nanocellulose as an additive in cosmetics, and microcellulose composites for the automotive industry. By employing a multidisciplinary strategy, SSbD4CHeM addresses key challenges in material innovation, ensuring regulatory compliance while reducing hazards to environmental and human health. The project will accelerate the development of next-generation sustainable materials, promoting industry innovation, regulatory progress, and improved consumer safety. Ultimately, SSbD4CheM aims to establish a new benchmark for the development of chemicals and materials that conform to safety and sustainability goals.
下一代化学品和材料的设计安全与可持续性（SSbD4CheM）项目的战略目标是为各种物质和材料制定筛选和测试策略，以确保符合可持续产品倡议的更安全、更可持续的产品。SSbD4CHeM正利用新方法，包括无动物模型研究和工具，专注于化学安全。此外，它将环境可持续性纳入设计安全与可持续性（SSbD）框架的实施，包括风险评估和生命周期评估。将开发、验证沿化学、材料和产品生命周期的安全与可持续性评估的新方法和模型，并将其应用于三个案例研究，包括用于纺织品的生物基自清洁、防水和抗菌处理、作为化妆品添加剂的纳米纤维素，以及用于汽车行业的微纤维素复合材料。通过采用多学科策略，SSbD4CHeM应对材料创新中的关键挑战，确保符合法规要求，同时减少对环境和人类健康的危害。该项目将加速下一代可持续材料的开发，促进产业创新、监管进展和提高消费者安全性。最终，SSbD4CheM旨在为符合安全与可持续性目标的化学品和材料开发树立新的标杆。
