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以手指骨髓炎为表现的系统性硬化症:医生在评估有指尖溃疡或感染的患者时,必须对系统性硬化症保持高度的怀疑指数。

Systemic Sclerosis Presenting as Osteomyelitis of the Finger: Physicians Must Maintain a High Index of Suspicion for Systemic Sclerosis when Evaluating Patients with Fingertip Ulceration or Infection.

作者信息

Poucke Logan Van, Hinton Jared B, Heck Holly C, Heck Benjamin E, Heck Bruce E

机构信息

Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, USA.

Department of Medicine, Northeast Ohio Medical University, Rootstown, Ohio, USA.

出版信息

J Orthop Case Rep. 2025 Apr;15(4):52-55. doi: 10.13107/jocr.2025.v15.i04.5442.

DOI:10.13107/jocr.2025.v15.i04.5442
PMID:40212482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11981491/
Abstract

INTRODUCTION

Osteomyelitis is a serious bone infection commonly caused by bacterial pathogens, with Staphylococcus aureus being the most prevalent. The condition poses significant challenges in patients with underlying autoimmune disorders such as scleroderma and Raynaud's syndrome, where vascular dysfunction and immunosuppression heighten infection risks. This case report illustrates the complex interplay between these conditions and underscores the importance of early diagnosis and comprehensive management to prevent severe complications.

CASE REPORT

We present the case of a 79-year-old female with a history of Raynaud's syndrome and suspected scleroderma who developed osteomyelitis of the left middle finger following a paronychial infection. The patient experienced persistent pain and swelling despite multiple debridement procedures. Physical examination revealed necrosis and gangrene of the affected finger, and magnetic resonance imaging confirmed osteomyelitis. Cultures identified Corynebacterium accolens, an uncommon pathogen in this context. The patient underwent surgical debridement, followed by antibiotic therapy and vasodilators. Her condition improved, with no signs of infection at follow-up.

CONCLUSION

This case highlights the critical need for early and thorough assessment of infections in patients with autoimmune conditions such as scleroderma and Raynaud's syndrome. The vascular dysfunction inherent in these diseases can exacerbate infections, leading to severe outcomes such as osteomyelitis. A multidisciplinary approach involving early surgical intervention and tailored medical management is essential to optimize patient outcomes.

摘要

引言

骨髓炎是一种严重的骨感染,通常由细菌病原体引起,其中金黄色葡萄球菌最为常见。对于患有潜在自身免疫性疾病(如硬皮病和雷诺综合征)的患者而言,这种疾病带来了重大挑战,因为血管功能障碍和免疫抑制会增加感染风险。本病例报告阐述了这些病症之间的复杂相互作用,并强调了早期诊断和综合管理对于预防严重并发症的重要性。

病例报告

我们报告一例79岁女性患者,有雷诺综合征病史且疑似硬皮病,在甲沟炎后发生左手中指骨髓炎。尽管进行了多次清创手术,患者仍持续疼痛和肿胀。体格检查发现患指坏死和坏疽,磁共振成像证实为骨髓炎。培养结果鉴定出痤疮棒状杆菌,在这种情况下这是一种不常见的病原体。患者接受了手术清创,随后进行抗生素治疗和血管扩张剂治疗。她的病情有所改善,随访时无感染迹象。

结论

本病例突出表明,对于患有硬皮病和雷诺综合征等自身免疫性疾病的患者,迫切需要对感染进行早期和全面评估。这些疾病固有的血管功能障碍会加重感染,导致诸如骨髓炎等严重后果。采用包括早期手术干预和量身定制的药物管理在内的多学科方法对于优化患者预后至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8b/11981491/d103760df309/JOCR-15-52-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8b/11981491/109994a6b417/JOCR-15-52-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8b/11981491/d103760df309/JOCR-15-52-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8b/11981491/109994a6b417/JOCR-15-52-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e8b/11981491/d103760df309/JOCR-15-52-g002.jpg

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