Oganov R G, Mustafaev I I, Perova N V, Metel'skaia V A, Postol'nikov S F
Kardiologiia. 1985 Apr;25(4):44-8.
The effect of an 8-week monotherapy with propranolol and pratsiol on plasma lipid levels and apo-Al and apo-B, apoproteins of high- and low-density lipoproteins (HDLP, LDLP) was studied in 20 patients with second-stage essential hypertension. Propranolol caused no significant changes in plasma lipid spectrum, however it produced a significant rise in apo-Al levels and reduced the cholesterol load index per weight unit of apo-Al in HDLP particles. Pratsiol treatment caused a significant reduction in plasma triglycerides, cholesterol of very-low-density lipoproteins, the cholesterol atherogenic coefficient and the apo-B/apo-Al ratio, and raised the level of HDLP cholesterol. The findings suggest that plasma lipoprotein effects should be taken into account in the choice of hypotensive agents.
在20例二期原发性高血压患者中，研究了普萘洛尔和鼠李素8周单一疗法对血脂水平以及高密度脂蛋白（HDLP）和低密度脂蛋白（LDLP）的载脂蛋白A1（apo - Al）和载脂蛋白B（apo - B）的影响。普萘洛尔未引起血脂谱的显著变化，但它使apo - Al水平显著升高，并降低了HDLP颗粒中每单位重量apo - Al的胆固醇负荷指数。鼠李素治疗使血浆甘油三酯、极低密度脂蛋白胆固醇、胆固醇致动脉粥样硬化系数和apo - B/apo - Al比值显著降低，并提高了HDLP胆固醇水平。研究结果表明，在选择降压药物时应考虑血浆脂蛋白效应。
