吲哚洛尔对轻至中度原发性高血压患者血脂、载脂蛋白及脂蛋白的影响。

Effects of pindolol on serum lipids, apolipoproteins, and lipoproteins in patients with mild to moderate essential hypertension.

作者信息

Sasaki J, Saku K, Ideishi M, Arakawa K, Kato Y, Kuwano E, So T

机构信息

Department of Internal Medicine, Fukuoka University Hospital, Japan.

出版信息

Clin Ther. 1989 Mar-Apr;11(2):219-24.

PMID:2736568

Abstract

The effects of 12 weeks' administration of the beta-blocker pindolol (5 mg twice daily) on serum lipids, apolipoproteins (apo), and lipoproteins were studied in 20 normolipidemic patients with mild to moderate essential hypertension (WHO I-II). Pindolol significantly increased both high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), while very-low-density lipoprotein cholesterol (VLDL-C) was significantly decreased. Apo A-II levels were increased significantly and the apo B/apo A-I ratio, which is one of the atherogenic indexes, was decreased significantly after pindolol therapy. Total cholesterol, HDL subfraction cholesterols, the LDL-C/HDL-C ratio, triglycerides, apo A-I, apo B, apo C-II, apo C-III, and apo E did not change significantly.

摘要

在20例轻度至中度原发性高血压（世界卫生组织I-II级）的血脂正常患者中，研究了给予β受体阻滞剂吲哚洛尔（每日两次，每次5毫克）12周对血清脂质、载脂蛋白（apo）和脂蛋白的影响。吲哚洛尔显著升高高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C），而极低密度脂蛋白胆固醇（VLDL-C）显著降低。吲哚洛尔治疗后，载脂蛋白A-II水平显著升高，作为致动脉粥样硬化指标之一的载脂蛋白B/载脂蛋白A-I比值显著降低。总胆固醇、HDL亚组分胆固醇、LDL-C/HDL-C比值、甘油三酯、载脂蛋白A-I、载脂蛋白B、载脂蛋白C-II、载脂蛋白C-III和载脂蛋白E无显著变化。