Bloomfield S E, Dunn M W, Miyata T, Stenzel K H, Randle S S, Rubin A L
Arch Ophthalmol. 1977 Feb;95(2):247-50. doi: 10.1001/archopht.1977.04450020048009.
This article reports a new concept in the treatment of tear film abnormalities. Solubilization of an artifical tear insert provides a continuous flow of polymer into the tear film in place of intermittent drop therapy. The physiochemical properties of succinylated collagen were studied in vitro and compared favorably with presently available tear substitutes. The use of this polymer as a solid solubilizable insert was evaluated in normal patients. It was found to be comfortable, resulted in no blurring of vision, and prolonged the tear film breakup time.
本文报道了一种治疗泪膜异常的新概念。人工泪液插入物的溶解可使聚合物持续流入泪膜，取代间歇性滴眼治疗。在体外研究了琥珀酰化胶原蛋白的物理化学性质，并与目前可用的泪液替代品进行了比较，结果良好。在正常患者中评估了这种聚合物作为固体可溶解插入物的使用情况。结果发现它使用起来很舒适，不会导致视力模糊，并且延长了泪膜破裂时间。
