Gautheron P D, Lotti V J, Le Douarec J C
Arch Ophthalmol. 1979 Oct;97(10):1944-7. doi: 10.1001/archopht.1979.01020020392026.
Unmedicated cellulose polymer (UCP) inserts exhibited marked superiority over six commercial artificial tear substitutes in enhancing and maintaining precorneal tear film stability as measured by tear film breakup time (BUT) in rabbits. The application of UCP inserts into one eye also resulted in an appreciable elevation of the BUT in the contralateral untreated eye. Sham inserts (polyethylene pieces) equal in size to our larger than UCP inserts lacked similar effects, which suggests that the latter actions of UCP inserts are most likely due to a slow release of polymer into the tear film rather than to induction of reflex responses associated with insertion of an inert foreign body into the cul-de-sac. The results indicate that UCP inserts, by virtue of their ability to maintain the integrity of the precorneal tear film over extended periods of time, may represent an important advance in the treatment of dry-eye diseases.
通过兔眼角膜泪膜破裂时间（BUT）测量发现，未用药的纤维素聚合物（UCP）插入物在增强和维持角膜前泪膜稳定性方面比六种市售人工泪液替代品表现出显著优势。将UCP插入物应用于一只眼睛也导致对侧未治疗眼睛的BUT明显升高。与我们较大尺寸的UCP插入物大小相同的假插入物（聚乙烯片）缺乏类似效果，这表明UCP插入物的后一种作用很可能是由于聚合物缓慢释放到泪膜中，而不是由于将惰性异物插入泪囊引起的反射反应。结果表明，UCP插入物凭借其在较长时间内维持角膜前泪膜完整性的能力，可能代表了干眼症治疗的一项重要进展。
